Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 485-420-6 | CAS number: 182918-16-7
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
With high probability acutely not harmful to aquatic invertebrates. No acute toxic effects occur within the range of solubility.
Key value for chemical safety assessment
Additional information
Data on the toxicity to aquatic invertebrates of an analogous substance (EC 440-520-9; CGX UVA 006) are available. CG 35-1597 and the analogous substance belong both to the Triphenyl-triazines (same common functional group) and CG 35-1597 is an intermediate for the synthesis of CGX UVA 006. Triphenyl-triazine are large, bulky, non-polar organic compounds used as UV-filter in varnishes and plastics.
CGX UVA 006 only differs from CG 35-1597 by a substituent at one phenol ring. It has an etherified branched carbonyl chain (C8) in para position instead of a hydroxyl group. The different substituents do not have any significant influence on the behaviour of the substances in the environment. Both substances have a very low water solubility (CG 35-1597 <0.0048 mg/L; CGX UVA 006 <0.73 mg/L), a low vapour pressure (CG 35-1597 = 5.3 E-19 Pa; CGX UVA 006 = 5.4 E-22 Pa), a high logPow above 3 (CG 35-1597 = 8.8; CGX UVA 006 = 10.7), a high molecular weight above 450 (CG 35 -1597 = 493.565; CGX UVA 006 = 605.78), are not readily biodegradable and due to the low water solubility hydrolysis is not expected. Both substances are stable and no degradation/breakdown products will occur in the environmental compartments. Due to the slightly higher water solubility and the slightly higher logPow of CGX UVA 006 the read across is justified and regarded as worst-case.
A detailed risk assessment and read across justification was send to the german chemical agency BAuA in 2007 with the purpose of a national substance notification (VIIA). The read across justification was accepted by the national agency.
A GLP guideline study on the toxicity of CGX UVA 006 to Daphnia magna is available (RCC Ltd. 2002). Due to the low water solubility of the test item, a supersaturated dispersion of the test item with a loading rate of 100 mg/L was tested. The undiluted filtrate with the maximum concentration of dissolved test item was used as test medium in a static test system set up according to OECD guideline 202. In the control and at the loading rate of 100 mg/L no immobilization or other signs of intoxication were determined during the test period of 48 hours.Therefore, an EC50 > 100 mg/l based on the loading rate was determined after 48 hours.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
