Registration Dossier
Registration Dossier
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EC number: 700-677-9 | CAS number: 19190-61-5
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 011
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 tris (Acute Oral Toxicity - Acute Toxic Class Method)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- methyl 2,2,3,3,4,4-hexafluoro-4-[(1,2,2-trifluoroethenyl)oxy]butanoate
- EC Number:
- 700-677-9
- Cas Number:
- 19190-61-5
- Molecular formula:
- C7H3F9O3
- IUPAC Name:
- methyl 2,2,3,3,4,4-hexafluoro-4-[(1,2,2-trifluoroethenyl)oxy]butanoate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- maize oil
- Remarks:
- lowest dose group only
- Doses:
- 2000 mg/kg bw
300 mg/kg bw
50 mg/kg bw - No. of animals per sex per dose:
- 2000 and 300 mg/kg bw group: 3 females each
50 mg/kg bw groups: 2 x 3 females - Control animals:
- yes
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 50 - < 300 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 2000 mg/kg bw group: 3/3
300 mg/kg bw group: 3/3
50 mg/kg bw group: 0/6 - Clinical signs:
- other: 2000 mg/kg bw group: Sluggishness (3/3), Blepharospasm (3/3), piloerection (3/3), coldness (3/3), coma 300 mg/kg bw group: Sluggishness (3/3), Blepharospasm (3/3), Ataxia (1/3), encrustation eye (1/3), piloerection (3/3), coldness (2/3), coma (2/3) 50 mg/
- Gross pathology:
- 2000 mg/kg bw group: No treatment related gross alterations.
300 mg/kg bw group: One animal showed pale kidneys and a dark liver. No treatment related gross alterations for the other animals of this group.
50 mg/kg bw groups: No treatment related gross alterations.
Applicant's summary and conclusion
- Interpretation of results:
- toxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The oral LD50 value is considered to be between 50 and 300 mg/kg bw. The test substance is considered to be toxic if swalloed.
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