Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 230-565-0 | CAS number: 7195-44-0
Endpoint summary
Administrative data
Description of key information
A primary skin irritation study was performed in rabbit and the substance was considered to be a slight skin irritant in the rabbit. An eye irritation test was also performed in rabbits and the substance was considered to be corrosive to eye. No data are available for respiratory irritation.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
One primary skin irritation study was conducted in rabbits and showed slight irritating effects.
The application of the test substance to the skin resulted in slight erythema on 3/6 intact and 6/6 abraded sites and very slight to slight oedema on 2/6 intact and 5/6 abraded sites. The substance is considered to be a slight primary skin irritant in the albino rabbit.
One eye irritation study was performed in rabbits. Due to the severity of the effects observed the three animals were sacrificed for animal welfare reasons after 6 days. The substance cause irreversible damage to the eyes.
Effects on skin irritation/corrosion: slightly irritating
Effects on eye irritation: corrosive
Effect level: empty Endpoint conclusion: Adverse effect observed
Justification for classification or non-classification
Based on the above stated assessment of the skin irritation potential of bis(2,3 -epoxypropyl)terephthalate the substance does have to be classified as R36: Irritating to skin according to Council Directive 2001/59/EC and Category 2 (H315 Causes skin irritation) according to CLP (Regulation (EC) No 1272/2008 Of the European parliament and of the Council.
Base on the above assessment of the eye irritation potential of bis(2,3 -epoxypropyl)terephthalate the substance does have to be classified as R41 Risk of serious damage to eyes according to Council Directive 2001/59/EC and Category 1 ( H318: Causes serious eye damage)according to CLP (Regulation (EC) No 1272/2008 Of the European parliament and of the Council.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
