Registration Dossier
Registration Dossier
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EC number: 204-688-5 | CAS number: 124-19-6
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Effect on fertility: via oral route
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEL
- 200 mg/kg bw/day
- Study duration:
- subchronic
- Species:
- rat
Effect on fertility: via inhalation route
- Endpoint conclusion:
- no study available
Effect on fertility: via dermal route
- Endpoint conclusion:
- no study available
Additional information
The test substance was assessed for toxicity to reproduction using a one-generation study in rats using the analogue substances 2,6-dimethylhept-5-enal and Heptanoic acid. The results showed that under the conditions of the test, dose levels of 300 mg/kg bw/day of 2,6-dimethylhept-5 -enal and dose levels of 200 mg/kg bw/day of Heptanoic acid had no adverse effects on the reproductive performance of female Sprague-Dawley rats or the growth or development of their offspring.
Short description of key information:
One generation studies were performed using analogue substances
2,6-dimethylhept-5-enal and Heptanoic acid. The NOAEL was 300 mg/kg
bw/day and 200 mg/kg bw/day respectively.
Justification for selection of Effect on fertility via oral route:
The No Observed Adverse Effect Level (NOAEL) for adult toxicity,
reproduction and offspring survival, growth and development was
considered to be 200 mg/kg bw/day.
Effects on developmental toxicity
Effect on developmental toxicity: via oral route
- Endpoint conclusion:
- no study available
Effect on developmental toxicity: via inhalation route
- Endpoint conclusion:
- no study available
Effect on developmental toxicity: via dermal route
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
According to Directive 67/548/EEC and Regulation (EC) 1272/2008, no classification is warranted.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
