Acetaldehyde oxime

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1975

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: Not GLP and not according to international test guideline. No detailed information about the protocol present.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1975

Report date:

1975

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

Twenty-five young adult albino rats (Wistar derived) weighing between 200-300 grams were administered a dose of acetaldehyde oxime via intragastric intubation. The animals were observed for 14 days following administration of the test material and deaths were recorded.

GLP compliance:

no

Remarks:

Study from 1975

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Acetaldehyde oxime

EC Number:

203-479-6

EC Name:

Acetaldehyde oxime

Cas Number:

107-29-9

Molecular formula:

C2H5NO

IUPAC Name:

acetaldehyde oxime

Details on test material:

- Test material: 50% AAO
- Appearance: water-white liquid

Test animals

Species:

rat

Strain:

Wistar

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Age: young adults
- Weight at study initiation: 200-300 g
- Fasting period before study: 24 h prior to dosing
- Housing: mesh bottom cages
- Diet: ad libitum
- Water: ad libitum

Administration / exposure

Route of administration:

oral: gavage

Doses:

0.31, 0.63, 1.25, 2.50, 5.0 mL/kg

No. of animals per sex per dose:

3 males and 2 females per dose

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of observations: daily

Statistics:

The acute oral toxicity LD50 for rats was calculated according to the method of Miller and Tainter (1944, Proc. Soc. Biol. Med. 57, 261).

Results and discussion

Effect levels

Effect levels 1

Sex:

male/female

Dose descriptor:

LD50

Effect level:

1.2 mL/kg bw

Based on:

test mat.

Remarks on result:

other: LD50 for 50% solution of AAO in water.

Effect levels 2

Sex:

male/female

Dose descriptor:

LD50

Effect level:

0.6 mL/kg bw

Based on:

act. ingr.

Remarks on result:

other: LD50 for AAO (undilluted)

Any other information on results incl. tables

Dosage Level (mL/kg)	Mortality after 14 days
0.31	0/5
0.63	0/5
1.25	3/5
2.50	5/5
5.0	5/5

Applicant's summary and conclusion

Interpretation of results:

sligthly toxic

Remarks:

Migrated information

Conclusions:

The approximate acute oral LD50 obtained for the 50% AAO solution in water is 1.20 mL/kg body weight as estimated by interpolation from the probit response curve. The LD50 for pure AAO is 0.6 mL/kg bw.

Executive summary:

25 young adult albino rats (Wistar derived) weighing between 200 -300 g were distributed into 5 dosage groups with 3 males and 2 females in each group. The animals were fasted 24 h prior to dosing. The test material was administered by oral gavaging. The animals were observed daily for 14 days following the adminitration of the test material.

The approximate acute oral LD₅₀ obtained for the test material is 1.20 mL/kg body weight as estimated by interpolation from the probit response curve.