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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Long-term toxicity to aquatic invertebrates

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Administrative data

Link to relevant study record(s)

Description of key information

Data are available for TAME and MTBE. For marine invertebrates the 28-d NOEC is 3.39 mg/l in Americamysis bahia for TAME.
The 21-d NOEC for MTBE in Daphnia magna is 51 mg/l, applying a safety factor of 10 results in an NOEC of 5.1 mg/l.
The outcome of these studies is used to support the derivation of an effect concentration as a weighted average of the predicted values for the components of the substance.

Key value for chemical safety assessment

Additional information

Based on the considerations described in the document “Read-across substantiation C5-6 branched alkylmethyl-ethers” (incl. the supporting references Tuppurainen et al., 2007 and Niska et al., 2008), it can be concluded that the available information can be usedto predict the long-term toxicity to aquatic invertebrates of the substance ‘C5-6 branched alkylmethyl-ethers’ with sufficient certainty.

In order to take the indicated higher ecotoxicological potential of the other components of the C5-6 branched alkylmethyl-ethers (compared to the TAME) into account, a weighted average value was calculated:

Endpoint

Weighted average (mg/l)

Chronic toxicity to daphnids

4.4

The outcome of the following studies is used to support the derivation of an effect concentration as a weighted average of the predicted values for the components of the substance (see attachments for details):

One chronic test with TAME in marine invertebrates is available; the study is conducted according to accepted guidelines. The 28-d NOEC inAmericamysis bahiais 3.39 mg/l (T.R. Wilbury Laboratories, Inc., 2004). No chronic studies with freshwater invertebrates are available. A guideline study is available for MTBE withDaphnia magna, the 21-d NOEC is 51 mg/l (Wildlife International Ltd., 1999). A safety factor of 10 is applied to this value, resulting in an effect concentration of 5.1 mg/l for TAME.