Pyrasulfotole

Solubility in organic solvents / fat solubility

Link to relevant study record(s)

Reference

Endpoint:

solubility in organic solvents / fat solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

8 May 2003 - 1 July 2003

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

comparable to guideline study

Qualifier:

equivalent or similar to guideline

Guideline:

other: OECD Guideline 105

Qualifier:

equivalent or similar to guideline

Guideline:

other: EU A.6

GLP compliance:

yes (incl. QA statement)

Remarks:

GLP certifying authority: ]Hess. Ministerium für Umwelt, Landwirtschaft und Forsten, Wiesbaden, Germany

Key result

Medium:

ethanol

Solubility:

21.6 g/L

Temp.:

20 °C

Key result

Medium:

other: n-hexane

Solubility:

0.038 g/L

Temp.:

20 °C

Key result

Medium:

toluene

Solubility:

6.86 g/L

Temp.:

20 °C

Key result

Medium:

other: dichloromethane

Solubility:

>= 120 - <= 150 g/L

Temp.:

20 °C

Key result

Medium:

acetone

Solubility:

89.2 g/L

Temp.:

20 °C

Key result

Medium:

ethyl acetate

Solubility:

37.2 g/L

Temp.:

20 °C

Key result

Medium:

DMSO

Solubility:

> 600 g/L

Temp.:

20 °C

Test substance stable:

not determined

Final Results

Direct Addition Method:

Defined volumes of the solvents dichloromethane and dimethyl sulfoxide were added to about 0.6 g test substance. The solubility of the test substance in the respective solvent was determined visually after 20 minutes. The solubility range in each one of the solvents is determined based on the added volume in which complete dissolution of the sample occurs.

 

Individual Results – Direct Addition

The results of the direct addition method are given below for dichloromethane and dimethyl sulfoxide.

Solvent	Solubility Range at 20°C (g/L)
Dichloromethane	120 - 150
Dimethylsulfoxide	>600

 

 Individual Results - Analytical Method

See materials and methods for details of the analytical method.

Solvent	ExperimentalData	Solubility at 20 °C (g/L)
Ethanol	Equilibrium approached from possible undersaturation	22.074
	Equilibrium approached from possible undersaturation	21.510
	Equilibrium approached from a condition of supersaturation	21.598
	Equilibrium approached from a condition of supersaturation	21.302
n-Hexane	Equilibrium approached from possible undersaturation	0.035
	Equilibrium approached from possible undersaturation	0.038
	Equilibrium approached from a condition of supersaturation	0.039
	Equilibrium approached from a condition of supersaturation	0.040
Toluene	Equilibrium approached from possible undersaturation	6.804
	Equilibrium approached from possible undersaturation	6.866
	Equilibrium approached from a condition of supersaturation	6.833
	Equilibrium approached from a condition of supersaturation	6.877

Solvent	ExperimentalData	Solubilityat20°C (g/L)
Acetone	Equilibrium approached from possible undersaturation	92.873
	Equilibrium approached from possible undersaturation	93.652
	Equilibrium approached from a condition of supersaturation	84.530
	Equilibrium approached from a condition of supersaturation	85.765
Ethylacetate	Equilibrium approached from possible undersaturation	37.486
	Equilibrium approached from possible undersaturation	38.400
	Equilibrium approached from a condition of supersaturation	34.950
	Equilibrium approached from a condition of supersaturation	38.041

Final Results

The solubility of the test substance has been determined at 20 °C in the organic solvents ethanol, n­ hexane, toluene, dichloromethane, acetone, ethylacetate and dimethyl sulfoxide 20°C. The results are presented below.

Solvent	Solubility at 20 °C
Ethanol	21.6 g/L
n-Hexane	0.038 g/L
Toluene	6.86 g/L
Dichloromethane	120-150 g/L
Acetone	89.2 g/L
Ethyl acetate	37.2 g/L
Dimethylsulfoxide	>600 g/L

Description of key information

Solubility in organic solvents at 20 °C:

ethanol                    21.6 g/L

n-hexane                 0.038 g/L

toluene                    6.86 g/L

dichloromethane       120 -150 g/L

acetone                     89.2 g/L

ethyl acetate             37.2 g/L

dimethylsulfoxide       > 600 g/L     

(OECD 105, flask method)