Registration Dossier
Registration Dossier
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EC number: - | CAS number: -
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2021-04-27
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Version / remarks:
- 2004
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- 2.41
- Temp.:
- 21.7 °C
- pH:
- 7
- Conclusions:
- The log Pow of the test item was determined to be 2.41 (weighted average mean) at 21.7°C under neutral condition.
- Executive summary:
The partition coefficient of test item was determined according to OECD guideline No.117 under GLP. Using HPLC-method the log Pow of the test item was determined to be 2.41 (weighted average mean of 3 signals) at 21.7°C under neutral condition.
Reference
Calculation of the Weighted Average Mean Value:
| Test item | 1st calibration | 2nd calibration | mean | Area [%] |
| 1st Signal | 1.71 | 1.71 | 1.71 | 21.2 |
| 2ndSignal | 1.79 | 1.79 | 1.79 | 4.0 |
| 3rd Signal | 2.64 | 2.64 | 2.64 | 74.8 |
Based on the area of three signals, the weighted average mean was calculated to be 2.41.
Description of key information
A study of the partition coefficient of test item was determined according to OECD guideline No.117 under GLP. Using HPLC-method the log Pow of the test item was determined to be 2.41 (weighted average mean of 3 signals) at 21.7°C under neutral condition.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 2.41
- at the temperature of:
- 21.7 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
