Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 289-964-3 | CAS number: 90045-98-0 Extractives and their physically modified derivatives such as tinctures, concretes, absolutes, essential oils, oleoresins, terpenes, terpene-free fractions, distillates, residues, etc., obtained from Simmondsia chinensis N., Buxaceae.
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 021
- Report date:
- 2021
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 492 (Reconstructed Human Cornea-like Epithelium (RhCE) Test Method for Identifying Chemicals Not Requiring Classification and Labelling for Eye Irritation or Serious Eye Damage)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Water
- EC Number:
- 231-791-2
- EC Name:
- Water
- Cas Number:
- 7732-18-5
- Molecular formula:
- H2O
- IUPAC Name:
- water
- Reference substance name:
- Jojoba Esters
- Cas Number:
- 61789-91-1
- IUPAC Name:
- Jojoba Esters
- Reference substance name:
- Alcohols, C14-22 and C16-22-unsatd.
- EC Number:
- 268-107-7
- EC Name:
- Alcohols, C14-22 and C16-22-unsatd.
- Cas Number:
- 68002-95-9
- IUPAC Name:
- Alcohols, C14-22 and C16-22 unsaturated
- Reference substance name:
- Fatty acids, C14-22 and C16-22-unsatd., potassium salts
- EC Number:
- 286-079-4
- EC Name:
- Fatty acids, C14-22 and C16-22-unsatd., potassium salts
- Cas Number:
- 85186-93-2
- IUPAC Name:
- Fatty acids, C14-22 and C16-22 unsaturated, potassium salts
- Test material form:
- semi-solid (amorphous): gel
Constituent 1
Constituent 2
Constituent 3
Constituent 4
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source (i.e. manufacturer or supplier) and lot/batch number of test material: SC21C31A
- Purity.: 100%
Test animals / tissue source
- Species:
- human
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent positive control
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 50 mg
- Concentration (if solution): 100%
- Duration of treatment / exposure:
- 50 mg of the undiluted test substance are applied on the top of each tissue for 6 hours ± 15 minutes
- Duration of post- treatment incubation (in vitro):
- 18 hours
- Number of animals or in vitro replicates:
- Test is performed in duplicate: 2 wells per test substance, 2 for positive control and 2 for negative control for each experimental condition
Results and discussion
In vitro
Results
- Irritation parameter:
- mean percent tissue viability
- Run / experiment:
- 2
- Value:
- >= 104.9 - <= 109.2
- Vehicle controls validity:
- valid
- Negative controls validity:
- valid
- Positive controls validity:
- valid
- Remarks on result:
- no indication of irritation
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The Test material is not an eye irritant.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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