Registration Dossier
Registration Dossier
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EC number: 221-650-3 | CAS number: 3177-22-8
Endpoint summary
Administrative data
Description of key information
Skin irritant.
Not eye irritant.
Key value for chemical safety assessment
Additional information
No experimental data on the skin and eye irritation potential of target substance was found in literature.
Based on the structural analysis performed by OECD QSAR Toolbox 4.0.0.26167, skin irritation/corrosion inclusion rules by BfR identify aromatic amines and sulphonic acids or their salts as structural alerts. In particular, it is stated that sulphonic salts Na/SO3 seem to be not irritant for 8/10, except when an amine is attached on the aromatic ring.
Target substance is an aromatic ring with sodium sulphonate and two -NH2 as functional groups; thus a potential for skin irritation may not be excluded.
As for the eye irritation/corrosion inclusion rules by BfR, inclusion rules are not met by the target substance; thus a potential or eye irritation may be excluded.
Further information are available in the attachment in IUCLID section 13.2.
Justification for classification or non-classification
Based on analysis of structural alerts by QSAR tools and available data on structural analogues, the substance is classified as skin irritant, H315, within the CLP Regulation (EC 1272/2008). No classification for eye irritation applies.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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