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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
melting point/freezing point
Remarks:
glass transition temperature
Type of information:
experimental study
Adequacy of study:
key study
Study period:
07 March - 16 September 2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2018
Report date:
2018

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
OECD Guideline 102 (Melting point / Melting Range)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.1 (Melting / Freezing Temperature)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EPA OPPTS 830.7200 (Melting Point / Melting Range)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
differential scanning calorimetry
Remarks:
glass transition temperature

Test material

1
Chemical structure
Reference substance name:
(2S)-6-fluoro-2-(oxiran-2-yl)chromane
EC Number:
930-889-9
Cas Number:
1219915-05-5
Molecular formula:
C11H11FO2
IUPAC Name:
(2S)-6-fluoro-2-(oxiran-2-yl)chromane
Test material form:
liquid
Details on test material:
Physical state: liquid
Appearence: light brown liquid
Specific details on test material used for the study:
- Batch n°: I16FB3013
- Analytical purity: 87.5%
- Expiration date: 07 June 2018
- Storage condition: at room temperature

Results and discussion

Melting / freezing point
Key result
Atm. press.:
1 013.25 hPa
Decomposition:
yes
Decomp. temp.:
> 175 °C
Remarks on result:
other: the glass transition temperature was determined to be -52.3°C
Remarks:
An orange molten residue remained after the preliminary and a dark yellow molten residue remained after the first main test, indicating reaction and/or decomposition.

Any other information on results incl. tables

Preliminary test

From the TGA curve it could be derived that the weight of the sample decreased significantly at 225°C. At 290°C

the sample weight has decreased by 25%. After the experiment, a orange residue residue remained in the sample container (original colour: yellow). The change of the colour indicated reaction and/or decomposition of the test item.

Main tests

During cooling a glass transition (TG) of the test item was observed between -50°C and -80°C. During heating a TG was observed between -75°C and -25°C. The inflection point was -52.422°C. Starting at 175°C, the DSC curve showed an endothermic effect. The effect was most likely due to the start of reaction and/or decomposition, based on the results obtained by the preliminary test and the change of colour. After the experiment, a dark yellow molten residue remained in the sample container.

 Experiment 2 was performed to determine the duplicate inflection point of the TG. The temperature program of the second experiment was stopped after the glass transition. The inflection point of the glass transition was -52.110°C. After the experiment, the residue remained in the sample container was unchanged.

The TGwas determined as the average glass transition obtained from Experiment 1 (-52.422°C) and Experiment 2 (-52.110°C).

Applicant's summary and conclusion

Conclusions:
The glass transition temperature of JNJ-42819543-AAA (T001596) was determined at -52.3°C (220.9K) by using DSC. No melting was observed.