Registration Dossier
Registration Dossier
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EC number: 229-828-2 | CAS number: 6770-38-3
Adsorption / desorption
Administrative data
Link to relevant study record(s)
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Oct 22, 2020
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- Version / remarks:
- 22 January, 2001
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC estimation method
- Media:
- soil
- Radiolabelling:
- no
- Test temperature:
- 30 ℃
- Details on study design: HPLC method:
- EQUIPMENT
- Apparatus: HPLC e2695-2489 (C2019-002), XS205 electronic balance (P-228)
- Column：ECLIPSE XDB-CN (4.6×250 mm, 5μm)
- Oven temperature： 30℃
- Detector: UV
- Detection wavelength: 254 nm
MOBILE PHASES
- Type: Methanol/Water = 60/40 (v/v)
- Flow rate：1.2 mL/min
- Injection volume：10.0 µL
DETERMINATION OF DEAD TIME
- Method: NaNO3 was employed to determine the dead time t0.
REFERENCE SUBSTANCES
- Identity: Six reference points, including phenol, atrazine, carbendazim, naphthalene, triazophos and phenanthrene, were used.
REPETITIONS
- Number of determinations: 2
EVALUATION
- Calculation of capacity factors k': k'=(tR-t0)/t0
- Calculation of retention times:
- Determination of the log Koc value: logKoc = a*logk'+b - Key result
- Type:
- log Koc
- Value:
- 1.59
- Temp.:
- 30 °C
- Details on results (HPLC method):
- In the first injection sequence, the retention time of the test item was 2.889 min, which was in the range of the retention times of the six reference substances. The calibration curve was LogKoc=4.5063×logk'+1.9833, and the calculated LogKoc value of the test item was 1.57.
In the second injection sequence, the retention time of the test item was 2.887 min, and the calibration curve was LogKoc=4.4176×logk'+2.0073, the calculated LogKoc value of the test item was 1.60.
The average LogKoc of the test item in the two injection sequences was 1.59, and the deviation was -0.03. - Validity criteria fulfilled:
- yes
- Conclusions:
- The estimated logKoc value of the test item was 1.59.
- Executive summary:
This test was performed according to the OECD121: Estimation of the Adsorption Coefficient(Koc) on soil and Sewage Sludge using High Performance Liquid Chromatography (HPLC), to estimate the logKoc of the test item.
The average LogKoc of the test item in the two injection sequences was 1.59, and the deviation was -0.03.
Reference
Description of key information
This test was performed according to the OECD121: Estimation of the Adsorption Coefficient(Koc) on soil and Sewage Sludge using High Performance Liquid Chromatography (HPLC), to estimate the logKoc of the test item.
The average LogKoc of the test item in the two injection sequences was 1.59, and the deviation was -0.03.
Key value for chemical safety assessment
Additional information
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