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EC number: 211-838-3 | CAS number: 700-13-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 970
- Report date:
- 1970
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Internal BASF method was used
- GLP compliance:
- no
- Remarks:
- pre-dates GLP
- Type of study:
- skin painting test
- Justification for non-LLNA method:
- old study report from 1970
Test material
- Reference substance name:
- 2,3,5-trimethylhydroquinone
- EC Number:
- 211-838-3
- EC Name:
- 2,3,5-trimethylhydroquinone
- Cas Number:
- 700-13-0
- Molecular formula:
- C9H12O2
- IUPAC Name:
- 2,3,5-trimethylhydroquinone
- Details on test material:
- - Name of test material (as cited in study report): 2,3,5-trimethylhydroquinone
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- female
- Details on test animals and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: mean 441.2 g
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Route:
- epicutaneous, open
- Vehicle:
- other: acetone
- Concentration / amount:
- Induction: 20% (2 applications); 50% (8 applications)
Challenge: 5%,
Rechallenge: 20%
Challengeopen allclose all
- Route:
- epicutaneous, open
- Vehicle:
- other: acetone
- Concentration / amount:
- Induction: 20% (2 applications); 50% (8 applications)
Challenge: 5%,
Rechallenge: 20%
- No. of animals per dose:
- 10
- Details on study design:
- MAIN STUDY
A. INDUCTION EXPOSURE
- No. of exposures: 10 applications
- Test groups: 10 animals
- Control group: 3 animals
- Site: ca. 25 cm2 clipped area of flank
- Frequency of applications: paintings were done three times in a row, for 5 days per week (together ten times in two weeks)
- Concentrations: 20% (2 applications), 50% (8 applications)
B. CHALLENGE EXPOSURE
- No. of exposures: 2
- Day(s) of challenge: first challenge 16 days after induction; second challenge 16 days after first challenge
- Test groups: 10 animals
- Control group: 3 animals
- Site: shaved right flank
- Concentrations: 5% (challenge), 20% (rechallenge)
- Evaluation (hr after challenge): 12 h - Challenge controls:
- Not treated during induction period
- Positive control substance(s):
- not specified
Results and discussion
In vivo (non-LLNA)
Resultsopen allclose all
- Key result
- Reading:
- 1st reading
- Hours after challenge:
- 12
- Group:
- test chemical
- Dose level:
- 5%
- No. with + reactions:
- 0
- Total no. in group:
- 10
- Remarks on result:
- other: Reading: 1st reading. . Hours after challenge: 12.0. Group: test group. Dose level: 5%. No with. + reactions: 0.0. Total no. in groups: 10.0.
- Key result
- Reading:
- rechallenge
- Hours after challenge:
- 12
- Group:
- test chemical
- Dose level:
- 20%
- No. with + reactions:
- 7
- Total no. in group:
- 10
- Remarks on result:
- other: Reading: rechallenge. . Hours after challenge: 12.0. Group: test group. Dose level: 20%. No with. + reactions: 7.0. Total no. in groups: 10.0.
- Key result
- Reading:
- 1st reading
- Hours after challenge:
- 12
- Group:
- negative control
- Dose level:
- 5%
- No. with + reactions:
- 0
- Total no. in group:
- 3
- Remarks on result:
- other: Reading: 1st reading. . Hours after challenge: 12.0. Group: negative control. Dose level: 5%. No with. + reactions: 0.0. Total no. in groups: 3.0.
- Key result
- Reading:
- rechallenge
- Hours after challenge:
- 12
- Group:
- negative control
- Dose level:
- 20%
- No. with + reactions:
- 0
- Total no. in group:
- 3
- Remarks on result:
- other: Reading: rechallenge. . Hours after challenge: 12.0. Group: negative control. Dose level: 20%. No with. + reactions: 0.0. Total no. in groups: 3.0.
- Key result
- Reading:
- 1st reading
- Hours after challenge:
- 12
- Group:
- positive control
- Dose level:
- 5%
- Remarks on result:
- not measured/tested
- Key result
- Reading:
- rechallenge
- Hours after challenge:
- 12
- Group:
- positive control
- Dose level:
- 20%
- Remarks on result:
- not measured/tested
Any other information on results incl. tables
1) Induction:
Repeated application of the test substance at 20% or 50% in acetone produced hemorrhagic encrustations in 10/10 animals of the test group. These symptoms were reversible within the 16-day rest period.
2) Challenge / rechallenge:
Single application of the 5% solution in acetone to the previously untreated site did not produce any skin response in the animals of the test group. In contrast, application of the 20% solution at 16 days later produced a slight erythema in 7/10 test animals. Control animals did not show any skin response after treatment with either 5% or 20%.
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (skin sensitising) based on GHS criteria
- Conclusions:
- The test substance trimethylhydroquinone was sensitizing to guinea-pigs under the test conditions chosen resulting in a classification to cause sensitization by skin contact according to CLP.
- Executive summary:
Under the above stated test conditions trimethylquinone causes degeneration of the tissue on repeated application of 1% and 10 % acetone solutions to the skin of guinea-pigs and also leads to sensitization of the skin. When applied as 20% and 50% solution in acetone, distinct tissue degeneration and slight sensitizing of the skin are observed.
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