Registration Dossier
Registration Dossier
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EC number: 246-148-1 | CAS number: 24308-84-7
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Low bioaccumulation potential.
Key value for chemical safety assessment
- Bioaccumulation potential:
- low bioaccumulation potential
Additional information
According to the Annex VIII of the REACH Regulation (EC 1907/2006), the assessment of the toxicokinetics behaviour of the substance should be done to the extent that can be derived from the relevant available information.
Based on the physicochemical properties of the substance (mainly physical state and particle size, chemical structure and functional groups, molecular weight, water solubility, octanol/water partition coefficient), absorption is expected to some extent, depending on tested species, exposure route, exposure duration...
In particular, absorption, distribution and excretion of test substance are controlled by:
1. ionic nature of the substance
2. molecular weight below 500 a.u of all moieties,
3. log Pow of -0.39 at 23 °C,
4. particle size distribution, i.e. 100 % of particles between 2 and 22 µm size;
5. water solubility of 886.9 mg/l at 20 °C and pH ca. 7.
As for the potential of bioaccumulation, it is expected to be low, based on log Pow below the threshold value of 4.
In available toxicological studies by oral route, i.e. acute toxicity and combined repeated dose toxicity and reproductive/developmental toxicity, systemic effects were evident, with different severity, depending on doses and duration of exposure. These findings proved absorption of test substance.
No experimental evidences of absorption by dermal route and by inhalation was available, however it was expected to be possible based on the physicochemical features of the substance.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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