Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 616-586-1 | CAS number: 78068-85-6
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 001
- Report date:
- 2001
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.2400 (Acute Eye Irritation)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- 2-chloro-1-fluoro-4-(trifluoromethyl)benzene
- EC Number:
- 616-586-1
- Cas Number:
- 78068-85-6
- Molecular formula:
- C7H3ClF4
- IUPAC Name:
- 2-chloro-1-fluoro-4-(trifluoromethyl)benzene
- Reference substance name:
- 1-Chloro-2-fluoro-4-(trifluoromethyl)benzene
- Cas Number:
- 32137-20-5
- Molecular formula:
- C7H3ClF4
- IUPAC Name:
- 1-Chloro-2-fluoro-4-(trifluoromethyl)benzene
- Test material form:
- liquid
Constituent 1
impurity 1
- Specific details on test material used for the study:
- Purity: 89.5 % [a/a]
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- Origin of animals: Charles River Deutschland GmbH, 88353 Kißlegg
Body weight at start of study: 3.89-3.98 kg
Individual housing
Humidity: 50+/- 20 %
Room temperatur:20+/-3 °C
Photoperiod: 12/12 h light/dark
Feeding: ssniff® K-H (V2333), ad libitum and hay (approx. 15 g/d)
Acclimatization: 1 week under study conditions
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes
- Amount / concentration applied:
- 0.1 ml per eye
- Duration of treatment / exposure:
- Administered once
- Observation period (in vivo):
- 72 hours
- Number of animals or in vitro replicates:
- 3
- Details on study design:
- About 24 hours before the start of the experiment the eyes of all animals were examined under UV-light for corneal lesions after instillation of one drop of a 0.01 % fluorescein-sodium solution.
Only animals without ocular abnormalities were used for this study.
0.1 ml of the test substance was administered once to the conjunctival sac of the left eye of 3 rabbits.
The untreated eye served in each case as a control.
The eyes were examined 1, 24, 48 and 72 hours after application of the testing substance. At 24 h and 72 h the eyes were also examined for corneal lesions under UV light after instillation of one drop of 0.01% of fluorescein-sodium solution.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.11
- Reversibility:
- fully reversible within: 48 hours
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Based on the results of this study 3-chloro-4-fluorobenzotrifluoride is not irritating to eye.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
