Registration Dossier
Registration Dossier
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EC number: 832-253-5 | CAS number: 12165-18-3
Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vitro
Description of key information
There is no experimental data available on gene mutation in bacteria for the substance dipraseodymium dizirconium heptaoxide. However, based on a weight of evidence approach including results of Ames tests performed with the constituents of the substance, i.e. praseodymium(III,IV) oxide and zirconium dioxide, it can be concluded that the substance is not expected to be mutagenic in bacteria either.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (negative)
Genetic toxicity in vivo
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
1. Information on praseodymium(III,IV) oxide
Mutagenic potential of praseodymium(III,IV) oxide was evaluated using an Ames test performed according to OECD guideline 471 and in compliance with GLP. Five strains of Salmonella typhimurium (TA 1535, TA 1537, TA98, TA 100 and TA 102) were used in this study and exposed to a concentration series of the test item in the presence and absence of metabolic activation (Haddouk, 2007; Klimisch 1). Under the conditions of this study, praseodymium(III,IV) oxide did not show any mutagenic activity in the Salmonella strains tested, both in the absence and presence of metabolic activation.
2. Information on zirconium dioxide
A similar GLP-compliant OECD 471 study is available for zirconium dioxide. Five strains of Salmonella typhimurium (TA 97a, TA 98, TA 100, TA 102, TA 1535) were tested in the presence and absence of metabolic activation (LAUS GmbH, 2008; Klimisch 1). Under the conditions of this study, zirconium dioxide was not found to be mutagenic in the absence and presence of metabolic activation in the Salmonella strains tested.
3. Conclusion on the substance dipraseodymium dizirconium heptaoxide:
Based on the negative results obtained for its constituents praseodymium(III,IV) oxide and zirconium dioxide, the substance can safely be concluded not to be mutagenic to bacteria either.
Justification for classification or non-classification
Based on the negative results obtained for its constituents, the substance dipraseodymium dizirconium heptaoxide can safely be concluded not to be mutagenic to bacteria either.
Neither praseodymium(III,IV) oxide nor zirconium dioxide is classified for genetic toxicity. Therefore, the reaction mass of these two oxides is not classified for genetic toxicity either.
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