Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 260-742-8 | CAS number: 57453-97-1
Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vitro
Description of key information
No genetic toxicity study with magnesium neodecanoate is available, thus the genetic toxicity will be addressed with existing data on the individual moieties magnesium and neodecanoate.
Magnesium neodecanoate is not expected to be genotoxic, since the two moieties magnesium and neodecanoic acid have neither shown a gene mutation potential in bacteria or mammalian cells nor clastogenicity in mammalian cells.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (negative)
Genetic toxicity in vivo
Description of key information
No genetic toxicity study with magnesium neodecanoate is available, thus the genetic toxicity will be addressed with existing data on the individual moieties magnesium and neodecanoate.
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
No genetic toxicity study with magnesium neodecanoate is available, thus the genetic toxicity will be addressed with existing data on the individual moieties magnesium and neodecanoate.
Magnesium
Results of several in vitro genetic toxicity studies and the crucial role of magnesium in cellular processes such as DNA-polymerase functioning and DNA repair processes show that magnesium has no genotoxic effects to human cells. All cells in every organism are highly dependent on magnesium maintaining their functionality. Therefore it appears highly unlikely that magnesium exerts any genotoxic or mutagenic effects to human cells. Based on the above existing information on the genotoxicity of magnesium substances and the weight of evidence information, magnesium is considered as not genotoxic. Thus, magnesium has no mutagenic potential and does not require classification according to Regulation (EC) No 1272/2008 and subsequent adaptations.
Neodecanoic acid
Neodecanoic acid has neither shown a gene mutation potential in bacteria or mammalian cells nor clastogenicity in mammalian cells.
Magnesium neodecanoate
Magnesium neodecanoate is not expected to be genotoxic, since the two moieties magnesium and neodecanoic acid have neither shown a gene mutation potential in bacteria or mammalian cells nor clastogenicity in mammalian cells. Further testing is not required. For further information on the toxicity of the individual moieties, please refer to the relevant sections in the IUCLID and CSR.
Justification for classification or non-classification
As the two moieties of magnesium neodecanoate do not have a genotoxic activity, magnesium neodecanoate in all probability has also no potential to induce genotoxic effects.
According to the criteria of REGULATION (EC) No 1272/2008 and its subsequent adaptions, magnesium neodecanoate does not have to be classified and has no obligatory labelling requirement for germ cell mutagenicity.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
