Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 266-737-7 | CAS number: 67584-59-2
Endpoint summary
Administrative data
Description of key information
Biodegradation of C4 sulfonamido methacrylate is addressed by readacross of data from C4 acrylate. The Target chemical and the Source chemical both contain the nonafluorobutylsulfon-N-methylamidoethoxyl (i.e., C4 sulfonamido alcohol) functionality. The Target chemical contains this structure esterified with methacrylic acid. The Source chemical contains the same group esterified with acrylic acid. The Source chemical and the Target chemical have similar molecular weights. Water solubility differs between the two chemicals by approximately a factor of ten, while octanol-water partition coefficient differs by less than one log unit. Acrylate and methacrylate functionalities are electrophilic and both may participate in Michael addition reactions. Metabolism is expected to occur through the same pathways, hydrolysis by carboxylesterases and conjugation to gluthathione. Hydrolysis is similar across the acrylate family and enhances the elimination of the chemical upon exposure (McCarthy & Witz (1997), Toxicol. 116, 153). Enzymatic hydrolysis kinetic constants for methacrylate and acrylate esters are similar. Because the Source and Target substances exhibit similarity in their structures, physicochemical properties and metabolic properties, data gaps for biodegradation can be addressed by read across. C4 acrylate was not readily biodegradable in a test conducted under test guideline OECD301B. C4 sulfonamido methacrylate is also expected not to be readily biodegradable.
Please see the Analogue Reporting Format, IUCLID Section 13, for further information justifying the readacross.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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