Registration Dossier
Registration Dossier
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EC number: 232-160-4 | CAS number: 7789-38-0
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1990
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
Data source
Reference
- Reference Type:
- publication
- Title:
- Toxicity and Carcinogenicity of Potassium Bromate - A New Renal Carcinogen
- Author:
- Yuji Kurokawa, Akihiko Maekawa, Michihito Takahashi, and Yuzo Hayashit
- Year:
- 1 990
- Bibliographic source:
- Environmental Health Perspectives Vol. 87, pp. 309-335, 1990
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- Deviations:
- not specified
- GLP compliance:
- no
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- Sodium bromate
- EC Number:
- 232-160-4
- EC Name:
- Sodium bromate
- Cas Number:
- 7789-38-0
- Molecular formula:
- BrHO3.Na
- IUPAC Name:
- sodium bromate
- Test material form:
- solid: granular
- Details on test material:
- Colorless crystalline powder.
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- other: S. typhimurium TA 97, TA 98, TA 100 and TA 102
- Metabolic activation:
- with and without
- Metabolic activation system:
- S9
Results and discussion
Test results
- Key result
- Species / strain:
- other: S. typhimurium TA 97, TA 98, TA 100 and TA 102
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
Applicant's summary and conclusion
- Conclusions:
- Under the experimental conditions described, the test item did not demonstrate mutagenic acivity with and without addition of S9 mix.
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