Registration Dossier
Registration Dossier
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EC number: 255-137-0 | CAS number: 40908-37-0
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 14.05.1996 to 02.10.1996
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 996
- Report date:
- 1996
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- N-(2,2,6,6-tetramethylpiperidin-4-yl)acetamide
- EC Number:
- 255-137-0
- EC Name:
- N-(2,2,6,6-tetramethylpiperidin-4-yl)acetamide
- Cas Number:
- 40908-37-0
- Molecular formula:
- C11H22N2O
- IUPAC Name:
- N-(2,2,6,6-tetramethylpiperidin-4-yl)acetamide
- Test material form:
- solid: crystalline
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: Kleine Weiße Russen, Mol:Russian / Chbb: HM
Test system
- Type of coverage:
- semiocclusive
- Vehicle:
- water
- Amount / concentration applied:
- Concentration: 0.5 g
- Duration of treatment / exposure:
- 4 hour(s)
- Number of animals:
- 5
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0.33
- Max. score:
- 4
- Reversibility:
- fully reversible
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0.33
- Max. score:
- 4
- Reversibility:
- fully reversible
Any other information on results incl. tables
3 min application: erytheme: 0 edema: 0 (one animal)
1 hour application: erytheme: 0 edema: 0 (one animal)
Primary irritation score, 4 hours application:
(mean 24, 48, 72 hours)
Erytheme: animal 1: 0 animal 2: 0 animal 3: 0.33
Edeme: animal 1: 0 animal 2: 0 animal 3: 0.33
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The results of the present study on skin irritation in rabbits do not show any signs for irritation. Thus, the available data on skin irritation of the test substance do not meet the criteria for classification according to Regulation (EC) 1272/2008, and are therefore conclusive but not sufficient for classification.
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