Registration Dossier
Registration Dossier
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EC number: 203-483-8 | CAS number: 107-35-7
Endpoint summary
Administrative data
Key value for chemical safety assessment
- Toxic effect type:
- dose-dependent
Effects on fertility
Effect on fertility: via oral route
- Endpoint conclusion:
- no adverse effect observed
Effects on developmental toxicity
Effect on developmental toxicity: via oral route
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEL
- 7 000 mg/kg bw/day
- Study duration:
- chronic
- Species:
- mouse
Toxicity to reproduction: other studies
Description of key information
Considering the overall weight of evidence and the SCF (1999, 2003) conclusion that taurine does not demonstrate any potential for teratogenicity, supplemental taurine intake is unlikely to exert adverse effects on reproductive or developmental parameters under the intended conditions of use.
Taurine passes to the developing fetus through maternal circulation during pregnancy and to the infant via breast milk. Mammalian fetuses and infants are dependent on taurine given maternally, either via the placenta or mother's milk; it is an important link in mother-fetus or mother-infant bonding.
An extensive review of the clinical use of taurine in humans in conditions including diabetes, epilepsy, congestive heart failure, hypertension, liver disease and cystic fibrosis, concluding that “No adverse health effects attributable to taurine have been reported in more than 30 clinical investigations reported over a period of 30 years. In many cases taurine has proved medically beneficial.” (SCF, 2003)
Justification for classification or non-classification
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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