Bis[N-(2-hydroxyethyl)-N-methylglycinato-N,O,ON]copper

Water solubility

Administrative data

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2016-12-22 to 2016-12-30

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2018

Report date:

2018

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Version / remarks:

1995

Deviations:

no

Test guideline 2

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

Version / remarks:

2008

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

flask method

Test material

Test material information

Constituent 1

Reference substance name:

Bis[N-(2-hydroxyethyl)-N-methylglycinato-N,O,ON]copper

EC Number:

300-491-4

EC Name:

Bis[N-(2-hydroxyethyl)-N-methylglycinato-N,O,ON]copper

Cas Number:

93940-93-3

Molecular formula:

C10H20CuN2O6

IUPAC Name:

bis[N-(2-hydroxyethyl)-N-methylglycinato-N,O,ON]copper

Test material form:

solid: particulate/powder

Results and discussion

Water solubility

Key result

Water solubility:

37.2 g/L

Conc. based on:

test mat.

Temp.:

20 °C

pH:

8.58

Any other information on results incl. tables

- Preliminary Test:

Approximate solubility was above 10 mg/L.

- Main Test:

In flask 1 2.496 g was weighed in 10 mL water, and in flask 2 2.2502 g in 10 mL water.

Results of the water solubility of test item: 

Time of shaking [h]	Analyte concentration Flask 1	Analyte concentration Flask 2	mean concentration [g/L]	pH value
25	36.4	37.0	36.7	8.56
49	36.6	37.3	37.0	8.58
70	38.3	37.3	37.8	8.61
		Mean:	37.2	8.58
		Standard deviation:	0.6	0.03
		Relative standard deviation[%):	1.6	0.3

The results indicate the required reproducibility (relative standard deviation below 15 %) and no tendency to increasing values, when the shaking time was prolonged.

Applicant's summary and conclusion

Conclusions:

The water solubility of the test item in ultra-pure water saturated with carbon dioxide at 20 ± 0.5°C was determined to be 37.2 g/L (pH 8.58).

Executive summary:

The solubility of test item was determined in ultra-pure water in equilibrium with atmospheric carbon dioxide at a temperature of 20±0.5 °C according to EC method A.6 (Regulation (EC) No 440/2008) and OECD guideline 105. The shake flask method was used, because the solubility determined in the preliminary test was above 10 mg/L.

The water solubility of the test item was determined to be 37.2 g/L (pH 8.58).

The results indicate the required reproducibility (relative standard deviation below 15 %) and no tendency to increasing values, when the shaking time was prolonged.