Registration Dossier
Registration Dossier
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EC number: 947-004-7 | CAS number: -
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- 1. HYPOTHESIS FOR THE ANALOGUE APPROACH
The substances have common functional groups, common precursor(s) and breakdown product(s). Therefore also a common mechanism(s) of action is expected.
2. SOURCE AND TARGET CHEMICAL(S) (INCLUDING INFORMATION ON PURITY AND IMPURITIES)
Please see attached Analogue Approach.
3. ANALOGUE APPROACH JUSTIFICATION
Please see attached Analogue Approach.
4. DATA MATRIX
Please see attached Analogue Approach. - Reason / purpose for cross-reference:
- read-across source
- Vehicle:
- no
- Duration:
- 24 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 72 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Key result
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Details on results:
- 100 mg of the test substance was mixed with 1 litre of water. this quantity, which was in excess of the water solubility (1 mg/L) of the same substance did not cause any disturbance to the fish. It was not
possible, with the analytical technology available to measure the concentration of the substance in the solution. - Validity criteria fulfilled:
- yes
- Conclusions:
- In an acute fish test Brachydanio rerio were 96 h exposed with a nominal concentration of 100 mg/L test substance. No toxicological effects occured. The LC50 was > 100 mg/L. The NOEC was 100 mg/L.
- Executive summary:
A group of 20 Brachidanio rerio was used, of which 10 were treated with the similar substance Butanedioic acid, 2,3-dihydroxy-di-C14-C15 alkyl esters at a concentration (100 mg/L dispersion concentration) exceeding the solubiliy of the substance (1 mg/L), 10 were used as a control, kept in the same conditions without adding the test material. During the study no toxic symptoms or mortality were observed in the treated and the control group.
The LC50 was > 100 mg/L.
Reference
Description of key information
A group of 20 Brachydanio rerio was used, of which 10 were treated with the similar substance Butanedioic acid, 2,3-dihydroxy-di-C14-C15 alkyl esters at a concentration (100 mg/L dispersion concentration) exceeding the solubility of the substance (1 mg/L), 10 were used as a control, kept in the same conditions without adding the test material. During the study no toxic symptoms or mortality were observed in the treated and the control group. The LC50 was > 100 mg/L. It is likely that the test substance has similar toxicological properties.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 100 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
