Reaction products of sodium glucoheptonate with manganese sulfate and sodium hydroxide

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

weight of evidence

Study period:

1984

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: The result of this study originates from a public peer-reviewed ATSDR report.

Data source

Reference

Reference Type:

publication

Title:

TOXICOLOGICAL PROFILE FOR MANGANESE

Author:

Agency for Toxic Substances and Disease Registry

Year:

2012

Bibliographic source:

U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES Public Health Service. Internet: http://www.atsdr.cdc.gov

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

A brief study result is reported.

GLP compliance:

no

Remarks:

result from a publication

Test type:

other: not reported

Test material

Test material information

Constituent 1

Reference substance name:

Manganese dioxide

EC Number:

215-202-6

EC Name:

Manganese dioxide

Cas Number:

1313-13-9

Molecular formula:

MnO2

IUPAC Name:

Manganese dioxide

Test material form:

not specified

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

not specified

Administration / exposure

Route of administration:

inhalation: dust

Type of inhalation exposure:

not specified

Vehicle:

not specified

Duration of exposure:

6 h

Remarks on duration:

During 10 days

Concentrations:

43 mg/m3

Results and discussion

Effect levels

Effect levels 1

Sex:

not specified

Dose descriptor:

discriminating conc.

Remarks:

LOAEC

Effect level:

43 mg/m³ air

Based on:

element (total fraction)

Remarks:

Manganese

Exp. duration:

6 h

Remarks on result:

other: during 10 days

Remarks:

(for respiratory effects). The effect is assigned as serious health effect.

Effect levels 2

Sex:

not specified

Dose descriptor:

other: NOAEC

Effect level:

138 mg/m³ air

Based on:

element (total fraction)

Remarks:

Manganese

Exp. duration:

6 h

Remarks on result:

other: during 10 days

Remarks:

(established for hematological effects)

Other findings:

Pneumonitis and increased lung weight were observed in treated animals.

Applicant's summary and conclusion

Conclusions:

A LOAEC of 43 mg Mn/m³ and a NOAEC of 138 mg Mn/m³ are reported for respiratory and hematological effects in rats.

Executive summary:

Acute inhalation exposure to high concentrations of manganese dusts (manganese dioxide, manganese tetroxide) can cause an inflammatory response in the lung, which can lead to impaired lung function and this is accompanied by increased numbers of macrophages and leukocytes in the lung (ATSDR, 2012). A LOAEC of 43 mg Mn/m³ and a NOAEC of 138 mg Mn/m³ are reported for respiratory and hematological effects in rats inhaled 6h/day during 10 days by Manganese dioxide (Shiotsuka, 1984). Since respiratory effects, which served as basis for setting LOAEL, were assigned as "serios" health effects, this study result has been taken into account for the read-across to the target substance MnGHA (see the target record).