Registration Dossier
Registration Dossier
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EC number: 907-132-6 | CAS number: -
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- read-across based on grouping of substances (category approach)
- Adequacy of study:
- supporting study
- Study period:
- Not specified but between 13 March and 31 May 1961
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: This study was conducted prior to GLP and test guidelines
- Justification for type of information:
- Read across is based on the category approach. Please refer to attached category document.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 961
- Report date:
- 1961
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- The dermal irritation of test material applied to the ear and intact and abraded abdomen of rabbit skin was examined.
- GLP compliance:
- no
Test material
- Reference substance name:
- 3,6,9-trioxaundecane-1,11-diol
- EC Number:
- 203-989-9
- EC Name:
- 3,6,9-trioxaundecane-1,11-diol
- Cas Number:
- 112-60-7
- Molecular formula:
- C8H18O5
- IUPAC Name:
- 2,2'-[oxybis(ethane-2,1-diyloxy)]diethanol
- Test material form:
- other: pale yellow liquid
- Details on test material:
- Polyol PS (tetraethylene glycol with 200 APHA) was used.
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: white
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- other: on abdomen: intact and abraded shaved skin
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Duration of treatment / exposure:
- See methodology below
- Observation period:
- Typically examined 24 hours after dosing. Since doses are repeated, animals are examined for three (abraded skin) or nine (intact skin).
- Number of animals:
- one rabbit
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- other: undiluted, intact ear, 9 applications
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- other: undiluted, intact belly, 9 applications
- Remarks on result:
- other: very slight hyperemia with some exfoliation after a week
- Irritation parameter:
- other: undiluted, abraded belly, 3 applications
- Remarks on result:
- other: very slight hyperemia and scar from the abrasion
- Other effects:
- Following 9 applications to the ear, there was no apparent effect noted.
Following 9 applications to the intact abdomen, very slight hyperemia with some exfoliation after a week was observed.
Following 3 applications to the abraded abdomen, very slight hyperemia and scar from the abrasion was observed.
Any other information on results incl. tables
Report does not state amount of test material applied to each site.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Exposure to the test material results in a very slight redness from repeated prolonged skin contact
- Executive summary:
The dermal irritation potential of tetraethylene glycol was examined with a rabbit. Undiluted test material produced very slight redness with some exfoliation after a week of repeated exposure to intact skin. On abraded skin, a slightly more severe effect was noted following 3 applications.
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