Registration Dossier
Registration Dossier
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EC number: 296-292-4 | CAS number: 92457-12-0
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation, other
- Remarks:
- HRIPT Human Repeated Insult Patch Test
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1995
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 995
- Report date:
- 1995
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: HRIPT 50 subjects
- Deviations:
- not specified
- Principles of method if other than guideline:
- - Principle of test:
Repeated Insult Patch Test 50 Subjects
- GLP compliance:
- yes (incl. QA statement)
- Type of study:
- patch test
- Justification for non-LLNA method:
- Human data available
Test material
- Reference substance name:
- Jojoba, ext., hydrogenated
- EC Number:
- 296-292-4
- EC Name:
- Jojoba, ext., hydrogenated
- Cas Number:
- 92457-12-0
- Molecular formula:
- No molecular formula is available since it is a UVCB substance
- IUPAC Name:
- Jojoba (Simmondsia Chinensis) Seed Oil Hydrogenated
- Test material form:
- solid: flakes
Constituent 1
In vivo test system
Test animals
- Species:
- other: Human
- Sex:
- male/female
Results and discussion
In vivo (non-LLNA)
Results
- Key result
- Reading:
- other: Readings at 24/48/72 h
- Hours after challenge:
- 72
- Group:
- test chemical
- Dose level:
- test material dilutet to 10% in mineral oil, occlusive
- No. with + reactions:
- 0
- Total no. in group:
- 53
- Clinical observations:
- one (I) subject exhibited a ± Ievel reaction at the 24 and 48 hour readings, which diminished to a zero (0) Ievel at the 72 hour reading.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Based on the test population of fifty-three (53) subjects and under the conditions of this study, the test material demonstrated no potential for eliciting either dermal irritation or sensitization
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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