Registration Dossier
Registration Dossier
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EC number: 219-529-5 | CAS number: 2455-24-5
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well-documented publication, which meets basic scientific principles
Data source
Reference
- Reference Type:
- publication
- Title:
- A 15-year study of patch testing to (meth)acrylates
- Author:
- Tucker SC, Beck MH
- Year:
- 1 999
- Bibliographic source:
- Contact Dermatitis 1999, 40: 278-279
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- patients with history of exposure to methacrylates were tested using Finn Chambers on Scanpor tape
- GLP compliance:
- not specified
- Type of study:
- patch test
Test material
- Reference substance name:
- Tetrahydrofurfuryl methacrylate
- EC Number:
- 219-529-5
- EC Name:
- Tetrahydrofurfuryl methacrylate
- Cas Number:
- 2455-24-5
- Molecular formula:
- C9H14O3
- IUPAC Name:
- (oxolan-2-yl)methyl 2-methylprop-2-enoate
- Details on test material:
- - Name of test material (as cited in study report): tetrahydrofurfuryl methacrylate
Constituent 1
In vivo test system
Test animals
- Species:
- human
Study design: in vivo (non-LLNA)
Induction
- Concentration / amount:
- 2%
Challengeopen allclose all
- Route:
- epicutaneous, occlusive
- Concentration / amount:
- 2%
Results and discussion
In vivo (non-LLNA)
Results
- Reading:
- other: 2 and 4 d after start of exposure
- Group:
- test chemical
- Dose level:
- 2%
- No. with + reactions:
- 5
- Total no. in group:
- 147
- Remarks on result:
- other: Reading: other: 2 and 4 d after start of exposure. Group: test group. Dose level: 2%. No with. + reactions: 5.0. Total no. in groups: 147.0.
Any other information on results incl. tables
440 patients with a history of exposure to (meth)acrylates were identified. Of those, 147 were tested for THFMA. 5/147 tested patients (3.4%) showed positive reactions in the patch test.
Applicant's summary and conclusion
- Interpretation of results:
- ambiguous
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- Patch testing of patients with a history of exposure to (meth)acrylates resulted in 5/147 (3.4%) positive cases for THFMA.
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