Registration Dossier
Registration Dossier
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EC number: 419-040-9 | CAS number: 89604-92-2 TAEM
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian germ cell study: cytogenicity / chromosome aberration
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
- Year:
- 1 992
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: EC-Guideline 92/69, B.12.
- GLP compliance:
- yes
- Type of assay:
- other: Non-bacteriological test in vivo - 6th amendment data
Test material
- Reference substance name:
- 2-mercaptobenzothiazolyl-(Z)-(2-aminothiazol-4-yl)-2-(tert-butoxycarbonyl) isopropoxyiminoacetate
- EC Number:
- 419-040-9
- EC Name:
- 2-mercaptobenzothiazolyl-(Z)-(2-aminothiazol-4-yl)-2-(tert-butoxycarbonyl) isopropoxyiminoacetate
- Cas Number:
- 89604-92-2
- Molecular formula:
- C20H22N4O4S3
- IUPAC Name:
- tert-butyl 2-{[(Z)-[1-(2-amino-1,3-thiazol-4-yl)-2-(1,3-benzothiazol-2-ylsulfanyl)-2-oxoethylidene]amino]oxy}-2-methylpropanoate
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- NMRI
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- dimethyl sulfoxide
- No. of animals per sex per dose:
- Male: CA 2000 mg/kg; No. of animals: 5; Sacrifice time: 24 hours
Male: CA 2000 mg/kg; No. of animals: 5; Sacrifice time: 48 hours
Female: CA 2000 mg/kg; No. of animals: 5; Sacrifice times: 24 hours
Female: CA 2000 mg/kg; No. of animals: 5; Sacrifice times: 48 hours
Results and discussion
Test results
- Toxicity:
- yes
- Remarks on result:
- other: n.a.
- Additional information on results:
- Observations:
Animal observation, mortality: no adverse test substance
related effects were noted
The number of micronucleated polychromatic erythrocytes was
not increased in comparison to negative controls.
Micronucleated PCE of the negative and positive controls
were in the historical range.
Applicant's summary and conclusion
- Conclusions:
- negative
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