Registration Dossier
Registration Dossier
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EC number: 817-198-7 | CAS number: 1273322-47-6
Endpoint summary
Administrative data
Description of key information
- Perdu-Durand et al (2006): Hexadecylamine biotransformation rates in carp and rainbow trout liver subcellular fractions, ERASM (http://www.erasm.org/Study/INRA_report-subcellular-C16PA-060701.pdf), 2006
BIODEGRATDATION IN WATER: SCREENING TESTS
The registration substance is readily biodegradable in an OECD Tests 301B.
BIODEGRADATION IN WATER AND SEDIMENT: SIMULATION TESTS
SEWAGE TREATMENT PLANT
C12 -18. 18u alkyl amines were tested in two OECD 303A Sewage treatment plant simulation test. The test substance showed very high elimination after having reached the plateau phase. The elimination was >99.8 % (removal via adsorption expected in the range of 2 - 5 % based on the discussed publication of Geerts et al (2015) results in primary biodegradation of 95 - 98 %) and this can be attributed to ultimate biodegradation as in the ready tests no recalcitrant metabolites were formed.
FRESHWATER AND MARINE WATER
No simulation tests are available but according the REACH Guidance R.16.5.4.5 Half-lives can be assigned based on the ready test result:
Half-life Freshwater 15d
Half-life Marine water 50d
BIODEGRADATION IN SOIL & SEDIMENT
Based on an OECD 307 test on Aerobic transformation in soil with 1 -Hexadecanamine the median half-life over the three soils tested is 16.9 d at the environmental temperature of 12 deg Celsius. This soil biodegradation half-life is used for freshwater sediment as well (see REACH Guidance R16). The value for bulk sediment is set at 169 d.
BIOTRANSFORMATION IN FISH
The registration substance is also rapidly metabolized in fish. Metabolic rates in fish were measured for 1-Hexadecanamine (C16 amine) using an in vitro method with carp hepatocytes (Perdu-Durand, 2006, http://www.erasm.org/Study/INRA_report-subcellular-C16PA-060701.pdf). For a carp with a mass of 438 g the kM was estimated to be 0.152 1/d for a fish assuming only arterial blood supply to the liver, whereas a rate of 1.024 d-1 was estimated considering both arterial and a portal blood supplies.
METABOLISM IN MICROOGRANISM
The registration substance is rapidly biodegraded by microorganisms available in water, sediment and soil. The first step is the oxidative fission of the nitrogen alkyl bond leading to the corresponding alkanal and subsequently alkanoic (fatty) acid as well as ammonium. The fatty acid is rapidly metabolised by beta oxidation (van Ginkel, Handbook of Detergents, Volume F, Environmental Impact, 2003, CRC).
Additional Literature
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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