Registration Dossier
Registration Dossier
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EC number: 280-489-7 | CAS number: 83567-04-8
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Study period:
- From January 19, 1999 to February 16, 1999
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- RA study
- Reason / purpose for cross-reference:
- read-across: supporting information
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- flask method
- Key result
- Water solubility:
- 64 800 mg/L
- Conc. based on:
- test mat.
- Loading of aqueous phase:
- 500 g/L
- Incubation duration:
- 3 h
- Temp.:
- 20 °C
- pH:
- 6.1
- Remarks on result:
- other: with a purity correction of 52% (w/w)
- Details on results:
- Water solubilities:
- With 12.7143 g/25mL + 2 dilutions (100 and 5x): 120120 mg/L
- With 12.6339 g/25mL + 2 dilutions (100 and 5x): 129200 mg/L
The water solubility at 20.0°C was corrected with respect to the purity of the test substance (52% w/w): 64800 mg/L. - Conclusions:
- Under the study conditions, the water solubilty of the substance could be considered to be 64800 mg/L at 20°C.
- Executive summary:
A study was conducted to determine the water solubility of the read across substance Reaktiv Scharlach F97 -0319 according to EU Method A.6, in compliance with GLP. Based on the results of a preliminary experiment where the solubility of the test substance was ca. 50 -100 g/L, the "flask method" was further selected. Two weighed amounts of the test substance (ca. 12.5 g) were added in portions to 25 mL of distilled water and stirred for 3 h at 20.0°C. Aliquots of the saturated aqueous phase were taken and centrifugated (15 min, 5000 rpm). A 1.0 mL aliquot of the residual pellet was diluted with water and filled up to 100 mL. A 5.0 mL aliquot of this solution was further taken and diluted with water to a volume of 25 mL. The concentration of the test substance was determined by HPLC. The water solubility was corrected with respect to the purity of the test substance (52% w/w). Under the study conditions, the water solubility of the substance coule be considered to be 64800 mg/L at 20.0°C (Mühlberger, 1999).
Reference
Description of key information
The water solubility was determined according to an acceptable scientific method (Fincham, 2016).
Key value for chemical safety assessment
- Water solubility:
- 125 000 mg/L
- at the temperature of:
- 20 °C
Additional information
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