Registration Dossier
Registration Dossier
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EC number: 226-942-4 | CAS number: 5570-77-4
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from peer-reviewed journal
Data source
Reference
- Reference Type:
- publication
- Title:
- Range-Finding Toxicity Data: List VII
- Author:
- Henry F. Smyth Jr. Ph.D. , Charles P. Carpenter Ph.D. , Carrol S. Weil , Urbano C. Pozzani , Jean A. Striegel & Judith S. Nycum
- Year:
- 1 969
- Bibliographic source:
- American Industrial Hygiene Association Journal, 30:5, 470-476, 1969
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as below
- Principles of method if other than guideline:
- Acute dermal toxicity study 2-Chlorobutane in rabbits
- GLP compliance:
- not specified
- Test type:
- other: No data
- Limit test:
- no
Test material
- Reference substance name:
- 2-Chlorobutane
- Cas Number:
- 78-86-4
- Molecular formula:
- C4H9Cl
- IUPAC Name:
- 2-Chlorobutane
- Details on test material:
- - Name of test material (as cited in study report): 2-Chlorobutane
- Molecular formula (if other than submission substance): C4H9Cl
- Molecular weight (if other than submission substance): 92.5681 g/mole
- Substance type: Organic
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): 2-Chlorobutane
- Molecular formula (if other than submission substance): C4H9Cl
- Molecular weight (if other than submission substance): 92.5681 g/mole
- Substance type: Organic
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- not specified
Administration / exposure
- Type of coverage:
- other: Dermal
- Vehicle:
- not specified
- Details on dermal exposure:
- not specified
- Duration of exposure:
- not specified
- Doses:
- 17460 mg/kg bw
- No. of animals per sex per dose:
- not specified
- Control animals:
- not specified
- Details on study design:
- not specified
- Statistics:
- not specified
Results and discussion
- Preliminary study:
- not specified
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 17 460 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 50 % mortality
- Mortality:
- 50 % mortality observed in treated rabbits.
- Clinical signs:
- other: not specified
- Gross pathology:
- not specified
- Other findings:
- not specified
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- LD50 was considered to be 17460 mg/kg bw when rabbits were treated with 2-Chlorobutane by single dermal application
- Executive summary:
In a acute dermal toxicity study, rabbits were treated with 2-Chlorobutane in the concentration of 17460 mg/kg bw orally. 50 % mortality was observed at 17460 mg/kg bw intreated rabbits. Therefore,LD50 was considered to be 17460mg/kg bw when rabbits were treated with 2-Chlorobutane by single dermal application
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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