Registration Dossier
Registration Dossier
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EC number: 274-977-9 | CAS number: 70880-03-4
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- yes
- Remarks:
- In preliminary test the initial amount of the substance was increased to 1 g on the basis of analytical experience. Water volumes have been increased at the same rate. The reason for this was an expectation of high water solubility.
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Key result
- Water solubility:
- 173.37 g/L
- Conc. based on:
- test mat.
- Temp.:
- 20 °C
- pH:
- 7.5
- Conclusions:
- Interpretation of results (migrated information): very soluble (> 10000 mg/L)Water solubility of the test substance, Reactive Violet 1, established by the flask method is 173.37 g/L.
- Executive summary:
Water solubility test was performed for the test substance, Reactive Violet 1. Flask method was used. Test was performed according to the Method A.6., Water Solubility, Council Regulation (EC) No.440/2008, Published in O.J. L 142, 2008. The concentration of the test substance in the aqueous solution was determined by HPLC.
Water solubility of the test substance, Reactive Violet 1, established by the flask method is 173.37 g/L.
Reference
Tab No. 1: Results of determination of test substance solubility in water by flask method
Day | pH of saturated solution | 1st injection (g/L) | 2nd injection (g/L) | Average of 1st and 2nd inj. (g/L) |
1st | 7.51 | 176.73 | 176.92 | 176.83 |
2nd | 7.50 | 171.73 | 172.02 | 171.87 |
3rd | 7.48 | 171.40 | 171.39 | 171.40 |
Overall Mean | 173.37 | |||
Standard deviation | 3.01 | |||
Description of key information
Interpretation of results (migrated information): very soluble (> 10000 mg/L) Water solubility of the test substance, Reactive Violet 1, established by the flask method is 173.37 g/L.
Key value for chemical safety assessment
- Water solubility:
- 173.37 g/L
- at the temperature of:
- 20 °C
Additional information
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