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EC number: 203-322-1 | CAS number: 105-68-0
Endpoint summary
Administrative data
Description of key information
Biodegradation in water
The test item 3-Methylbutyl propanoate undergoes 45.9 % biodegradation after 42 days in the test condition. Thus, the test item was considered to be ultimate inherently biodegradable.
Biodegradation in water and sediment
Estimation Programs Interface (EPI Suite, 2017) prediction model was run to predict the half-life in water and sediment for the test compound 3-Methylbutyl propanoate (CAS No. 105 -68 -0). If released in to the environment, 35.4% of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of 3-Methylbutyl propanoate in water is estimated to be 15 days (360 hrs). The half-life (15 days estimated by EPI suite) indicates that the chemical is not persistent in water and the exposure risk to aquatic animals is moderate to low whereas the half-life period of 3-Methylbutyl propanoate in sediment is estimated to be 135 days (3240 hrs). However, as the percentage release of test chemical into the sediment is less than 1% (i.e, reported as 0.144%), indicates that 3-Methylbutyl propanoate is not persistent in sediment.
Biodegradation in soil
The half-life period of 3-Methylbutyl propanoate (CAS No. 105 -68 -0) in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (EPI suite, 2017). If released into the environment, 52.5% of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of 3-Methylbutyl propanoate in soil is estimated to be 30 days (720 hrs). Based on this half-life value of 3-Methylbutyl propanoate, it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is moderate to low.
Additional information
Biodegradation in water
Experimental data for the target compound 3-Methylbutyl propanoate (CAS No. 105-68-0) were reviewed for the biodegradation end point which are summarized as below:
42-days Closed Bottle test following the OECD guideline 301 D to determine the ready biodegradability of the test item. The study was performed at a temperature of 20°C. The test system included control, test item and reference item. Polyseed were used for this study. 1 polyseed capsule were added in 500 ml D.I water and then stirred for 1 hour for proper mixing and functioning of inoculum. This gave the bacterial count as 107 to 108 CFU/ml. At the regular interval microbial plating was also performed on agar to confirm the vitalityand CFU count of microorganism.
The concentration of test and reference item (Sodium Benzoate) chosen for both the study was 4 mg/L, while that of inoculum was 32 mg/l. OECD mineral medium was used for the study. ThOD (Theoretical oxygen demand) of test and reference item was determined by calculation. % degradation was calculated using the values of BOD and ThOD for test item and reference item. The % degradation of procedure control (reference item) was also calculated using BOD & ThOD and was determined to be 45.9%. Degradation of Sodium Benzoate exceeds 49.3 9% on 7 days & 75.30% on 14th day. The activity of the inoculum is thus verified and the test can be considered as valid. The BOD42 value of test chemical was observed to be 1.12 mgO2/mg. ThOD was calculated as 2.24 mgO2/mg. Accordingly, the % degradation of the test item after 42 days of incubation at 20 ± 1°C according to Closed Bottle test was determined to be 45.9 %. Based on the results, the test item, under the test conditions, was considered to be ultimate inherently biodegradable in nature.
In an experimental key study from peer reviewed journal (A.M. Api, et. al; 2017), biodegradation experiment was conducted for 28 days for evaluating the percentage biodegradability of test substance 3-Methylbutyl propanoate (CAS no. 105-68-0). The study was performed according to OECD Guideline 301 F (Ready Biodegradability: Manometric Respirometry Test).The percentage degradation of test substance 3-Methylbutyl propanoate was determined to be 74% by O2 consumption parameter in 28 days. Thus, based on percentage degradation, 3-Methylbutyl propanoate is considered to be readily biodegradable in nature.
By considering detailed guideline study 301D, the test chemical showed 49.9% degradation in 42 days. On the basis of this value, it is concluded that the substance is ultimate inherently biodegradable.
Biodegradation in water and sediment
Estimation Programs Interface (EPI Suite, 2017) prediction model was run to predict the half-life in water and sediment for the test compound 3-Methylbutyl propanoate (CAS No. 105 -68 -0). If released in to the environment, 35.4% of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of 3-Methylbutyl propanoate in water is estimated to be 15 days (360 hrs). The half-life (15 days estimated by EPI suite) indicates that the chemical is not persistent in water and the exposure risk to aquatic animals is moderate to low whereas the half-life period of 3-Methylbutyl propanoate in sediment is estimated to be 135 days (3240 hrs). However, as the percentage release of test chemical into the sediment is less than 1% (i.e, reported as 0.144%), indicates that 3-Methylbutyl propanoate is not persistent in sediment.
Biodegradation in soil
The half-life period of 3-Methylbutyl propanoate (CAS No. 105 -68 -0) in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (EPI suite, 2017). If released into the environment, 52.5% of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of 3-Methylbutyl propanoate in soil is estimated to be 30 days (720 hrs). Based on this half-life value of 3-Methylbutyl propanoate, it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is moderate to low.
On the basis of available information, the test substance 3-Methylbutyl propanoate can be considered to be readily biodegradable in nature.
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