Registration Dossier
Registration Dossier
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EC number: 264-133-8 | CAS number: 63422-71-9
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Justification for type of information:
- 1. SOFTWARE
ECOSAR Profile
2. MODEL (incl. version number)
ECOSAR Version 1.11
3. SMILES OR OTHER IDENTIFIERS USED AS INPUT FOR THE MODEL
CCN1CCN(C(=O)NC(C(=O)(O))c2ccccc2)C(=O)C1(=O)
4. SCIENTIFIC VALIDITY OF THE (Q)SAR MODEL
- Defined endpoint: Daphnid
5. APPLICABILITY DOMAIN
- Structural and mechanistic domains: Carbonyl Ureas -acid
Data source
Reference
- Reference Type:
- other: QSAR
- Title:
- EPI Suite Version 4.11_ECOSAR v1.11 Class-specific Estimations
- Author:
- US EPA
- Year:
- 2 014
- Bibliographic source:
- http://epa.gov/oppt/exposure/pubs/episuite.htm
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: REACH Guidance on QSARs R.6
- GLP compliance:
- no
Test material
- Reference substance name:
- (R)-[[(4-ethyl-2,3-dioxopiperazin-1-yl)carbonyl]amino]phenylacetic acid
- EC Number:
- 264-133-8
- EC Name:
- (R)-[[(4-ethyl-2,3-dioxopiperazin-1-yl)carbonyl]amino]phenylacetic acid
- Cas Number:
- 63422-71-9
- Molecular formula:
- C15H17N3O5
- IUPAC Name:
- (2R)-2-[(4-ethyl-2,3-dioxopiperazine-1-carbonyl)amino]-2-phenylacetic acid
Constituent 1
Results and discussion
Effect concentrations
- Key result
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- 1 942.679 mg/L
- Nominal / measured:
- estimated
- Conc. based on:
- not specified
- Basis for effect:
- mortality
- Remarks on result:
- not determinable because of methodological limitations
Applicant's summary and conclusion
- Conclusions:
- LC50 (48h) of 1942.679 mg/l is predicted.
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