Registration Dossier
Registration Dossier
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EC number: 620-459-6 | CAS number: 130841-23-5
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1990
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- fixed dose procedure
Test material
- Reference substance name:
- 1,4-dichloro-2-(1,1,2,3,3,3-hexafluoropropoxy)-5-nitrobenzene
- EC Number:
- 620-459-6
- Cas Number:
- 130841-23-5
- Molecular formula:
- C9H3Cl2F6NO3
- IUPAC Name:
- 1,4-dichloro-2-(1,1,2,3,3,3-hexafluoropropoxy)-5-nitrobenzene
Constituent 1
Test animals
- Species:
- rat
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: 6 to 8 weeks
- Initial body weight range: 170 to 215 g
- Fasting period before study: fasted overnight
- Housing: housed in Macrolon cages type 4, with standardized soft wood bedding
- Diet (e.g. ad libitum): yes
- Water (e.g. ad libitum): yes
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): ca. 22°C
- Humidity (%): ca. 55%
- Air changes (per hr): ca. 15
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: Ol. arachidis Ph. H. VI
- Doses:
- Dose levels / sex group: - 1000 mg/kg, males and femals; - 2000 mg/kg, males and femals
- No. of animals per sex per dose:
- 5 per sex / per dose
20 animals total
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 1 000 - < 2 000 mg/kg bw
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 1 000 - < 2 000 mg/kg bw
- Mortality:
- daily; a.m. and p.m. on working days
a.m. on weekend days - Clinical signs:
- daily for 14 days
- Body weight:
- immediately before administration, on days 7, 14 and at death
- Gross pathology:
- Spontaneously dying animals were submitted to a gross necropsyas soon as possible; survivors at the and of the observation period
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
