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Physical & Chemical properties

Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Justification for type of information:
Experimental test result performed using standard test guidelines
Qualifier:
according to guideline
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
GLP compliance:
no
Type of method:
HPLC method
Partition coefficient type:
octanol-water
Analytical method:
high-performance liquid chromatography
Key result
Type:
log Pow
Partition coefficient:
3.748
Temp.:
25 °C
pH:
7.05

Table 1:

Test substance

K

Logk

logPow by Generalized Calibration Graph

Mean of LogPow ± S.d

Tr1

3.8

3.231

0.509

3.748

3.748 ± 0.002

Tr2

3.811

3.243

0.51

3.749
Conclusions:
The partition coefficient (n-octanol/water) of test chemical was determined as per the HPLC method (OECD Guideline-117). The Log Pow value was determined to be 3.748 at 25°C.
Executive summary:

The Partition Coefficient n-octanol/water of test chemical was determined by the Reverse Phase High Performance Liquid Chromatographic method according to OECD Guideline No. 117 for testing of Chemicals.The reference substances were chosen according to functional similarity with the test substance and calibration graph was prepared. The reference substances were Benzophenone, Benzene, Biphenyl, 1,4- Dichlorobenzene, 1,2,4-Trichlorobenzene, Triphenylamine, Nitrobenzene, Naphthalene having Pow value ranging from 1.9 to 5.7 The Log Pow value was determined to be 3.748 ± 0.002 at 25°C.Thus it can be concluded that the test chemical is hydrophilic in nature . 

Description of key information

The Partition Coefficient n-octanol/water of test chemical was determined by the Reverse Phase High Performance Liquid Chromatographic method according to OECD Guideline No. 117 for testing of Chemicals.The reference substances were chosen according to functional similarity with the test substance and calibration graph was prepared. The reference substances were Benzophenone, Benzene, Biphenyl, 1,4- Dichlorobenzene, 1,2,4-Trichlorobenzene, Triphenylamine, Nitrobenzene, Naphthalene having Pow value ranging from 1.9 to 5.7 The Log Pow value was determined to be 3.748 ± 0.002 at 25°C.

Key value for chemical safety assessment

Log Kow (Log Pow):
3.748
at the temperature of:
25 °C

Additional information

The Partition Coefficient n-octanol/water of test chemical was determined by the Reverse Phase High Performance Liquid Chromatographic method according to OECD Guideline No. 117 for testing of Chemicals.The reference substances were chosen according to functional similarity with the test substance and calibration graph was prepared. The reference substances were Benzophenone, Benzene, Biphenyl, 1,4- Dichlorobenzene, 1,2,4-Trichlorobenzene, Triphenylamine, Nitrobenzene, Naphthalene having Pow value ranging from 1.9 to 5.7 The Log Pow value was determined to be 3.748 ± 0.002 at 25°C.


 


Similarly data from various authoritative databases suggests that the estimated log Pow of test chemical was 3.79.Thus it can be concluded that the test chemical is hydrophilic in nature .