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Diss Factsheets
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EC number: 246-014-2 | CAS number: 24085-08-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
The test substance was tested for mutagenic potential in the Bacterial reverse mutation assay at concentrations up to 5000 µg/plate using the following strains: TA 98 and TA100. The test substance induced 4.5 and 4.0 fold increase in the number of revertant colonies in the TA 100 strain, in the absence and presence of metabolic activation, respectively.
Consequently, the test substance was assessed for its ability to induce micronuclei in immature polychromatic erythrocytes in mouse bone marrow following intraperitoneal exposure to the maximum tolerated dose of 300mg/kg. No statistically significant decreases in the PCE/NCE ratio were observed in the 24 or 48 hr test material dose groups, compared to the concurrent control groups; however there were marked reductions in the PCE/NCE ratio at both exposure times ion animals treated with 300mg/kg test material. This accompanied with the presence of clinical signs was taken to indicate that systemic absorption has occurred and exposure of the bone marrow achieved.
There were no statistically significant increases in the frequency of micronucleated PCEs in any of the test material dose groups when compared to the concurrent controls and it was concluded that the test material was considered to be non-genotoxic under the conditions of the test.
Justification for selection of genetic toxicity endpoint
OECD guideline study conducted to GLP as part of the integrated testing strategy for genetic toxicity
Short description of key information:
The results of the assay demonstrated that there were no significant increases in micronucleated PCE compared to vehicle controls at the concentrations tested.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
The results of the in vivo bone marrow micronucleus test conducted in mice, demonstrated a lack of genotoxic potential with respect to there being no increases in micronucleus frequency in immature erythrocytes. On this basis there is insufficient evidence to justify a classification for germ cell mutagenicity despite the results observed in the bacterial reverse mutation screening assay.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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