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EC number: 309-066-8
CAS number: 99811-75-3
One experimental study of reliability
1 (based on international guideline and GLP compliance) and two QSAR
Holistic HA-QSAR v1.5) are available to assess the aquatic toxicity of
the registered substance, on aquatic invertebrates and algae. The
results are presented in the table below.
Table 6.1/1: Summary of aquatic
toxicity data available
(iSafeRat® Holistic HA-QSAR v1.5)
Short-term toxicity to aquatic invertebrates
48h-EL50 = 7.77 mg/L (nominal loading values)
48h-EL50 = 4.4 mg/L
Toxicity to aquatic algae
72h-ErL50 = 11 mg/L
The experimental short-term toxicity
study on the aquatic invertebrate, Daphnia magna, was performed
on the registered substance. In this study, the 48h-EL50 value, based on
nominal loading values, was determined at 7.77 mg/L (95%-Confidence
Limit: 6.85 – 8.90 mg/L) where the major constituent was measured and
found to be stable over the study period.
Based on this data, the QSAR result
obtained on daphnids supports the experimental study and can be
considered slightly conservative compared to the in vivo result
but strongly supports the validity of the QSAR and its usefulness as a
predictor of ecotoxicity for this substance. For the algae endpoint, the
same calculation method was used (iSafeRat Holistic HA-QSAR v1.5). Thus
the prediction method can be considered sufficient to assess the
toxicity of the registered substance to algae. The 72h-ErL50 based on
growth rate of algae was determined to be 11 mg/L. An in vivo algae
study is therefore not considered necessary.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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