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Diss Factsheets

Physical & Chemical properties

Particle size distribution (Granulometry)

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Reference
Endpoint:
particle size distribution (granulometry)
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
test procedure in accordance with national standard methods
Justification for type of information:
Experimental result using standard method of analysis
Qualifier:
according to guideline
Guideline:
other: as mention below
Principles of method if other than guideline:
The particle size distribution was determined with the help of Rotap sieve shaker.
GLP compliance:
no
Type of method:
sieving
Type of particle tested:
primary particle
Type of distribution:
mass based distribution
Key result
Percentile:
D50
Remarks on result:
other: Mass median diameter
No.:
#1
Size:
150 µm
Distribution:
28.6 %
Remarks on result:
other: No other detail available
No.:
#2
Size:
106 µm
Distribution:
27.33 %
Remarks on result:
other: No other detail available
No.:
#3
Size:
75 µm
Distribution:
38.75 %
Remarks on result:
other: No other detail available
No.:
#4
Size:
53 µm
Distribution:
1.74 %
Remarks on result:
other: No other detail available
No.:
#5
Size:
25 µm
Distribution:
1.05 %
Remarks on result:
other: No other detail available

There was some loss of particles that remain adhered within the mesh of the finest sieve

Conclusions:
The particle size distribution of test item was determined by granulometric analysis with rotap sieve shaker. The particle size distribution was determine to be in the range of 150 micron to 25 micron. Thus, it is concluded that the majority of the particle size of the chemical is is not in the inhalable size which is less than 10 microns.
Executive summary:

The particle size distribution of test item was determined by granulometric analysis with rotap sieve shaker. The particle size distribution was determine to be in the range of 150 micron to 25 micron. Thus, it is concluded that the majority of the particle size of the chemical is is not in the inhalable size which is less than 10 microns.

Description of key information

The particle size distribution of test item was determined by granulometric analysis with rotap sieve shaker. The particle size distribution was determine to be in the range of 150 micron to 25 micron. Thus, it is concluded that the majority of the particle size of the chemical is is not in the inhalable size which is less than 10 microns.

Additional information

The particle size distribution of test item was determined by granulometric analysis with rotap sieve shaker. The particle size distribution was determine to be in the range of 150 micron to 25 micron. Thus, it is concluded that the majority of the particle size of the chemical is is not in the inhalable size which is less than 10 microns.