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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed

Acute toxicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed

Acute toxicity: via dermal route

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed

Additional information

No acute toxicity studies with molybdic acid are available, thus the acute toxicity was addressed with existing data on molybdenum compounds. Experimental investigations in laboratory animals on acute toxicity after oral, dermal or inhalation exposure are available for a number of soluble and moderately soluble molybdenum substances, including molybdenum trioxide, sodium molybdate, ammonium dimolybdate and roasted molybdenite concentrate.

Summary of acute toxicity data of Molybdenum substances:

   Disodium molybdate (CAS#7631 -95 -0) Diammonium dimolybdate (CAS#27546 -07 -2)  Molybdenum trioxide (CAS#1313 -27 -5)   Molybdenum sulfide (MoS2), roasted (CAS#86089 -09 -0)
 Acute oral toxicity LD50(rat, male)=4040 mg/kg bwLD50(rat, female)=4461 mg/kg bw LD50(rat, male)=3884 mg/kg bwLD50(rat, female)=3883 mg/kgbw  LD50(rat, male)=2689 mg/kg bwLD50(rat, female)=3830 mg/kg bw  LD50>5000 mg/kg bw
 Acute dermal toxicity  LD50>2000 mg/kg bw  LD50>2000 mg/kg bw  LD50>2000mg/kg bw  LD50>2000 mg/kg bw
 Acute inhalation toxicity  LC50>1.93 mg/L (max attainable concentration)  LC50>2.08 mg/L (max attainable concentration)  LC50>5.84 mg/L (highest concentration required by guideline) LC50>3.92 mg/L ( max attainable concentration) 

All available acute oral LD50 (covering a large range of solubilities and valencies) are in excess of 2,000 mg/kg. Given that it has been shown for all molybdenum substance groups that the only species formed upon contact with aqueous media is the molybdate anion, read-across among all molybdenum substances is considered justified without restriction. In consequence, no classification is required for acute oral toxicity as well as for specific target organ toxicity, single exposure.

Regarding acute dermal toxicity, the LD50 of soluble and moderately soluble molybdenum substances was determined to be larger than the limit test dose of 2000 mg/kg in all tests. In consequence, no classification is required for acute dermal toxicity as well as for specific target organ toxicity, single exposure.

In acute inhalation toxicity studies, there was a complete absence of mortalities in all studies covering the range of soluble and moderately soluble molybdenum substances. Correspondingly, the LC50(4h) for all tested substances was either above the maximum attainable test concentration or the limit test concentration. As a consequence, no classification for acute inhalation toxicity as well as for specific target organ toxicity, single exposure is required for molybdic acid.


Justification for selection of acute toxicity – oral endpoint
Read-across information.

Justification for selection of acute toxicity – inhalation endpoint
Read-across information.

Justification for selection of acute toxicity – dermal endpoint
Read-across information.

Justification for classification or non-classification

Based on the classification criteria laid down in Regulation (EC) No 1272/2008, molybdic acid does not require classification for acute toxicity as well as for specific target organ toxicity, single exposure. This conclusion is based on standard experimental investigations in laboratory animals with other molybdenum compounds.