Registration Dossier
Registration Dossier
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EC number: 419-370-3 | CAS number: 84632-66-6
Endpoint summary
Administrative data
Description of key information
Two studies in rabbits were performed to evaluate irritating or corrosive properties of the test material to skin or eyes. Application of the test substance did not provoke skin irritation. Treatment of rabbits eyes caused slight, transient opacity and conjuctival irritation. All reaction on skin and eyes has resolved within 8 days or were below treshold of regualtion. Therefore, the substance is considered to be as not-irritating.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Procedure and observation
Two studies were performed to evaluate irritating potential of the test material to skin or eyes. In the first study, three rabbits (2 female, 1 male) were each administered a single dermal dose of 0.5 g of the test substance. Semiocclusive application of the test material to intact rabbit skin for four hours did not cause any reaction on animals skin.
In a second study, three rabbits were each administered a single ocular dose of 0.1 g of the test substance and observed for seven days after instillation.
Discussion
Application of the test substance onto skin and installation into the eye did not cause corrosion or irritation. The test item is therefore not considered to tbe irritating to skin or eyes.
Justification for classification or non-classification
Dangerous Substance Directive (67/548/EEC)
The available studies are considered reliable and suitable for classification purposes under 67/548/EEC. As a result the substance is not considered to be classified as irritating for skin or eyes under Directive 67/548/EEC.
Classification, Labelling, and Packaging Regulation (EC) No. 1272/2008
The available experimental test data are reliable and suitable for classification purposes under Regulation 1272/2008. As a result the substance is not considered to be classified for irritation under Regulation (EC) No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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