Registration Dossier
Registration Dossier
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EC number: 209-057-8 | CAS number: 554-00-7
Specific investigations: other studies
Administrative data
- Endpoint:
- nephrotoxicity
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data given
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Acute nephrotoxicity induced by isomeric dichloroanilines in Fischer 344 rats
- Author:
- Lo HH, Brown PI, and Rankin GO
- Year:
- 1 990
- Bibliographic source:
- Toxicology 63: 215-231
- Reference Type:
- publication
- Title:
- Acute nephrotoxicity induced by chlorinated anilines
- Author:
- Lo HHS
- Year:
- 1 989
- Bibliographic source:
- Dissertetion. West Virginia University
Materials and methods
- Principles of method if other than guideline:
- The nephrotoxic potential of 2,4-dichloroaniline isomers was examined. Male rats were administered a single, intraperitoneal injection of 2,4-dichloroaniline as the hydrochlorid salt or given vehicle (0.9% saline), and renal function monitored at 24 and 48 hours.
- GLP compliance:
- not specified
- Type of method:
- in vivo
Test material
- Reference substance name:
- 2,4-dichloroaniline
- EC Number:
- 209-057-8
- EC Name:
- 2,4-dichloroaniline
- Cas Number:
- 554-00-7
- Molecular formula:
- C6H5Cl2N
- IUPAC Name:
- 2,4-dichloroaniline
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Fischer 344
- Sex:
- male
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- physiological saline
- Analytical verification of doses or concentrations:
- no
- Frequency of treatment:
- once
- Post exposure period:
- 24 or 48 hours
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0.4, 0.8, or 1.0 mmol/kg
Basis:
nominal conc.
- No. of animals per sex per dose:
- from minimal of 4 rat to maximum of 8 rats
- Control animals:
- no
Results and discussion
- Details on results:
- Three of eight animals died in the 2,4-DCA (0.8 mmol/kg) treatment group.
Any other information on results incl. tables
BUN concentration was increased on day 2 following administration of 2,4 -dichloroaniline. TEA uptake was not reduced in any treatment group but was increased in the 2,4 -dichloroaniline (0.4 or 0.8 mmol/kg)
In vitro effects of dichloroanilines isomers
The overall in vitro effects of the dichloroanilines isomers on organic ion accumulation were similar. All compounds decreased lactate-stimulated PAH and TEA accumulation at a bath concentration of 10 -3 M. None of the compunds were able to inhibit TEA or lactate-stimulated PAH accumulation at concentration of 10-5M or less
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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