Registration Dossier
Registration Dossier
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EC number: 200-879-2 | CAS number: 75-56-9
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study, predates GLP, available as unpublished report, minor limitations in reporting but otherwise adequate for assessment.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 968
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Methyloxirane
- EC Number:
- 200-879-2
- EC Name:
- Methyloxirane
- Cas Number:
- 75-56-9
- Molecular formula:
- C3H6O
- IUPAC Name:
- 2-methyloxirane
- Details on test material:
- No data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Carworth Farm E , Manor Farm
- Age at study initiation: 12 weeks
- Weight at study initiation: 150-250 gram
- Fasting period before study: 4 pm- 10am
- Housing: 5 per cage
- Diet : ad libitum after dosing
- Water : ad libitum
- Acclimation period:14 days
ENVIRONMENTAL CONDITIONS
recorded but reported
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- all liquids were given undiluted by intubation in single doses on a ml/kg basis.
- Doses:
- in ml/kg not specified; only reported as LD50
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
- Statistics:
- By probit analysis. and by use of Weil's tables of moving averages.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 382 - 587 mg/kg bw
- Mortality:
- no data
- Clinical signs:
- other: no data
- Gross pathology:
- no data
Any other information on results incl. tables
No details on findings were reported, except the LD 50 values.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
