Poly(oxy-1,2-ethanediyl), α-[2-(dide- cylmethylammonio)ethyl]- .omega.- hydroxy-, propanoate (salt) (Bardap 26)

Bioaccumulation: aquatic / sediment

Link to relevant study record(s)

Reference

Endpoint:

bioaccumulation in aquatic species: fish

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

key study

Justification for type of information:

The read across to Bardap 26 is supported by a set of bridging studies for DDAC and ADBAC demonstrating the similarity in physico-chemical, toxicological, ecotoxicological and movement and fate properties of these quaternary substances. The quaternary ammonium compound (Bardap 26) for which read across is requested, and the two substances used for read across (DDAC and ADBAC) belong to the family of cationic surfactants. Within this family they form a well-defined subgroup of substances with similar chemical structure; (1) one or two hydrophobic, non-branched alkyl chains with a main chain length distribution of C10-16, (2) one to three methyl group substituents and (3) a hydrophilic group carrying a positively charged quaternary nitrogen atom.

Reason / purpose for cross-reference:

read-across source

Type:

BCF

Value:

38 dimensionless

Basis:

edible fraction

Time of plateau:

10 d

Calculation basis:

steady state

Remarks on result:

other: predicted BCF = 52

Remarks:

Conc.in environment / dose:93 ± 32 µg/l

Type:

BCF

Value:

140 dimensionless

Basis:

non-edible fraction

Time of plateau:

10 d

Calculation basis:

steady state

Remarks on result:

other: Predicted BCF = 160

Remarks:

Conc.in environment / dose:93 ± 32 µg/l

Key result

Type:

BCF

Value:

81 dimensionless

Basis:

other: whole body

Remarks on result:

other: Predicted BCF = 95

Elimination:

yes

Parameter:

other: Elimination after 14 Days 57% (edible tissue)

Elimination:

yes

Parameter:

other: Elimination after 18 Days 38% (edible tissue)

Elimination:

yes

Parameter:

other: Elimination after 14 Days 71% (non-edible tissue)

Elimination:

yes

Parameter:

other: Elimination after 18 Days 66% (non-edible tissue)

Key result

Elimination:

yes

Parameter:

other: Elimination after 14 Days 67% (whole body)

Elimination:

yes

Parameter:

other: Elimination after 18 Days 56% (whole body)

Description of key information

One key study is available which was conducted in accordance with US EPA Guideline 165-4 using Bluegill fish as the test species, exposed to the test material at concentrations of 0 and 59.0 µg/l for 28 days exposure period. Under the conditions of this study, for edible tissue, the BCF was 38 (predicted 52) and elimination after 14 and 18 Days was 57% and 38%, respectively. For non-edible tissue, the BCF was 140 (predicted 160) and elimination after 14 and 18 Days was 71% and 66%, respectively. For whole-body, the BCF was 81 (predicted 95) and elimination after 14 and 18 Days was 67% and 56%, respectively.

Key value for chemical safety assessment

BCF (aquatic species):

81 dimensionless

Additional information

In a study conducted in accordance with U.S.EPA (1989), Bluegill fish (Lepomis macrochirus) was exposed to the test material, Bardac 22 with radiolabelled Didecyldimethylammonium Chloride at concentrations of 0, 59.0 µg/l (actual concentration - 93 ± 32 µg/l). 220 bluegill were tested at each concentration. The test organisms were exposed to the test material in aquaria for 28 days, with an 18 day depuration period. Fish were collected on days 4, 10, 17, 24 and 28 of the exposure and on days 3, 7, 14 and 18 of depuration. Tissues from control fish were sampled on days 0 and 28 of exposure and day 18 of depuration. On day 28 of exposure, an additional five fish were sampled and divided into three tissue portions; edible (fillets), non-edible (head, fins and viscera) and skin. Edible tissues from each of three sets of approximately 10 fish sampled on day 28 were subjected to hexane/methanol tissue extraction, combusted and then counted to quantify that portion of the ¹⁴C-residue not extractable with either solvent. Five treated fish died during the exposure test and no fish died during depuration. Under the conditions of this study, for edible tissue, the BCF was 38 (predicted 52) and elimination after 14 and 18 Days was 57% and 38%, respectively. For non-edible tissue, the BCF was 140 (predicted 160) and elimination after 14 and 18 Days was 71% and 66%, respectively. For whole-body, the BCF was 81 (predicted 95) and elimination after 14 and 18 Days was 67% and 56%, respectively. In conclusion, Skin tissue showed ¹⁴C-residues 2 to 6 times higher than edible tissue portions. The test substance may bind significantly to skin and scales of exposed fish. Of the accumulated ¹⁴C-residue in the edible tissue of bluegill exposed 28 days to the test substance, 65.5% was extractable with a polar solvent (methanol), 8.1% was extractable with a nonpolar solvent (hexane) and 25.9% was not extractable with either solvent.