Registration Dossier
Registration Dossier
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EC number: 231-598-3 | CAS number: 7647-14-5
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: The report does not contain sufficient information to permit a meaningful evaluation of study results
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- The study methodology followed appeared to equivalent or similar to OECD 405
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Sodium chloride
- EC Number:
- 231-598-3
- EC Name:
- Sodium chloride
- Cas Number:
- 7647-14-5
- Molecular formula:
- ClNa
- IUPAC Name:
- sodium chloride
- Details on test material:
- - Name of test material (as cited in study report): Salt, common salt, halite, table salt, rock salt, sea salt
- Molecular weight: 58.45
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- not specified in the report
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- 100 mg dry powder
- Duration of treatment / exposure:
- not specified in the report
- Observation period (in vivo):
- up 72 hours
- Number of animals or in vitro replicates:
- 6 rabbits
- Details on study design:
- not specified in the report
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 24 hours
- Score:
- 18.2
- Max. score:
- 110
- Reversibility:
- not specified
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 48 hours
- Score:
- 5.3
- Max. score:
- 110
- Reversibility:
- not specified
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 72 hours
- Score:
- 3.5
- Max. score:
- 110
- Reversibility:
- not specified
- Irritant / corrosive response data:
- The mean scores at 24, 48 and 72 hours were 18.2, 5.3 and 3.5 out of a maximum score of 110
- Other effects:
- not specified in the report
Any other information on results incl. tables
not applicable
Applicant's summary and conclusion
- Interpretation of results:
- no data
- Remarks:
- Migrated information Criteria used for interpretation of results: not specified
- Conclusions:
- The report does not contain sufficient information on the interpretation of the scores so obtained at 24, 48 and 72 hours.
- Executive summary:
Eye irritation was evaluated in rabbits and the study methodology followed appeared to equivalent or similar to OECD 405. The report does not contain sufficient information on the interpretation of the scores so obtained at 24, 48 and 72 hours.
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