Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 209-062-5 | CAS number: 554-13-2
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption
- Type of information:
- other: Expert statement
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- other: expert statement
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2010
Materials and methods
Test guideline
- Qualifier:
- no guideline required
- GLP compliance:
- no
Test material
- Reference substance name:
- Lithium carbonate
- EC Number:
- 209-062-5
- EC Name:
- Lithium carbonate
- Cas Number:
- 554-13-2
- Molecular formula:
- CH2O3.2Li
- IUPAC Name:
- dilithium carbonate
Constituent 1
Results and discussion
Any other information on results incl. tables
Due to the chemical properties of an inorganic salt , the dermal absorption of lithium carbonate is expected to be very poor. Based on (1) the hydrophilic character of lithium carbonate and (2) the barrier function of the stratum corneum against salts, dermal absorption can practically be excluded. Dermal toxicity values revealed LD50 values > 2000 mg/kg bw, which further supports this conclusion. 10 % absorption was used for DNEL deduction. Thus, this presents a worst case.
Applicant's summary and conclusion
- Conclusions:
- The absorption of lithium carbonate through skin is considered to be very poor.
- Executive summary:
Expert statement: Due to the chemical properties of an inorganic salt, the dermal absorption of lithium carbonate is expected to be very poor. Based on (1) the hydrophilic character of lithium carbonate and (2) the barrier function of the stratum corneum against salts, .
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
