Registration Dossier
Registration Dossier
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EC number: 202-509-5 | CAS number: 96-48-0
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
Impairment of Growth Concentration 50% (IGC50): 4518 mg/L, Tetrahymena pyriformis
Key value for chemical safety assessment
- EC50 for microorganisms:
- 4 518 mg/L
Additional information
The toxicity of γ-butyrolactone (GBL) to microorganisms has been tested under non-GLP conditions according to methods that examine growth inhibition of Pseudomonas putida and Tetrahymena pyriformis. In addition, ready biodegradation and inherent biodegradation tests have been performed which provide insight into the degree of toxicity to microorganisms. For studies having a Klimisch score of at least 2, the data are as follows: No toxicity was observed at 1061 mg/L as part of an OECD 302B inherent biodegradability test (BASF, 1977), a 17 hour EC50 of >10000 mg/L was reported from a Growth Inhibition (Pseudomonas putida) test (BASF, 1988), and an IGC50 of 4518 mg/L was reported in a ciliated growth inhibition test with Tetrahmena pyroformis (Schultz, 1999). Given these results, it can be concluded that GBL exhibits a low order of toxicity to microorganisms.
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