Registration Dossier
Registration Dossier
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EC number: 205-524-5 | CAS number: 142-16-5
Repeated dose toxicity: other routes
Administrative data
- Endpoint:
- repeated dose toxicity: other route
- Remarks:
- other: Safety Assessment Evaluation
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Well document literature review on maleic acid
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 2 007
Materials and methods
Test material
- Reference substance name:
- Maleic acid
- EC Number:
- 203-742-5
- EC Name:
- Maleic acid
- Cas Number:
- 110-16-7
- Molecular formula:
- C4H4O4
- IUPAC Name:
- but-2-enedioic acid
- Details on test material:
- Maleic Acid (CAS no. 110-16-7 and 6915-18-0) is a cis unsaturated organic acid.
Constituent 1
Results and discussion
Results of examinations
- Details on results:
- Maleic Acid at the use levels is not expected to produce dermal or systemic toxicity.
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
see executive summary
Applicant's summary and conclusion
- Conclusions:
- Authors concluded that maleic acid is safe for use in cosmetic formulations as a pH adjuster.
- Executive summary:
Maleic acid is used in cosmetics as a pH adjuster and an ingredient in fragrances and non-cosmetic. Other uses include artificial resins, dyeing, and finishing wool, cotton, and silk, in salts of antihistamines, and as preservative for oils and fats. Animal toxicity data reported nephrotoxicity in rats and dogs associated with maleic acid injection. Data showed that maleic acid induce Fanconi syndrome in rats and dogs. Maleic Acid at the use levels is not expected to produce dermal or systemic toxicity.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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