Registration Dossier
Registration Dossier
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EC number: 238-034-5 | CAS number: 14177-55-0
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
In vitro
Mutagenicity in bacteria:The mutagenic potential of Molybdenum nickel tetraoxide was determined in the Ames test using five genetically manipulated Salmonella typhimurium strains (TA 97a, TA 98, TA100, TA 102 and TA1535) with and without metabolic activation according to OECD Guideline 471 and EU B.13/14. None of the concentrations caused a significant increase in the number of revertant colonies in the tested strains using the plate incorporation and the pre-incubation method (Paulus, 2010).
Short description of key information:
in vitro:
- mutagenicity in bacteria:
Ames, S. typhimurium TA 97a, TA 98, TA 100, TA 102, TA 1535, +/- S9, plate incubation and pre-incubation method: negative (Paulus, 2010)
Moreover, there are various in vitro and in vivo cytogenicity studies available demonstrating a genotoxic potential of soluble Nickel compounds.
Endpoint Conclusion:
Justification for classification or non-classification
Molybdenum nickel tetraoxide is classified as Muta. Cat. 3; R68 “Possible risk of irreversible effects" and as Muta 2 "May cause genetic defects” according to the criteria of Directives 67/548/EEC (DSD) and 1272/2008/EC (CLP).
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