Registration Dossier
Registration Dossier
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EC number: 202-576-0 | CAS number: 97-36-9
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Insufficient description of effect dose.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: company guideline, Similar to H.F.Smyth et al Am. Ind.Hyg.Ass.J. 23, 95-107 (1962)
- Deviations:
- no
- Principles of method if other than guideline:
- Inhalation of an atmosphere saturated with volatile parts of the substance for 7 h at room temperature. 200 liters of air were passed through a 5 cm thick layer of the test substance in order to prepare a saturated atmosphere.
- GLP compliance:
- no
- Remarks:
- prior to GLP implementation
- Test type:
- other: inhalation risk test
- Limit test:
- yes
Test material
- Reference substance name:
- 2',4'-dimethylacetoacetanilide
- EC Number:
- 202-576-0
- EC Name:
- 2',4'-dimethylacetoacetanilide
- Cas Number:
- 97-36-9
- Molecular formula:
- C12H15NO2
- IUPAC Name:
- 2',4'-dimethylacetoacetanilide
- Details on test material:
- - Name of test material (as cited in study report): Acetessig-m-xylidid
Constituent 1
Test animals
- Species:
- rat
- Sex:
- not specified
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 7 h
- Concentrations:
- atmosphere saturated with volatile parts
- No. of animals per sex per dose:
- 12 animals per dose
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- other: inhalation risk
- Effect level:
- other: atmosphere saturated with volatile parts
- Based on:
- test mat.
- Exp. duration:
- 7 h
- Remarks on result:
- other: no effect
- Mortality:
- 0/12
- Clinical signs:
- other: no abnormal findings
- Gross pathology:
- no abnormal findings
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- Under the conditions of this test method no inhalation risk was discovered.
- Executive summary:
Inhalation of an atmosphere saturated with volatile parts of the substance for 7 h at room temperature caused no lethality. Examination of clinical signs and gross pathology revealed no abnormal findings.
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